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Studies Found: 234

A Study of Single IV Dose of UX701 for Patients with Wilson Disease

(IRB#: IRB_00154398)

UX701is a medication for patients with Wilson's disease. Research is needed to learn the safety and effectiveness of single IV doses of UX701. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

165-306: Pegvaliase in adolescents with Phenylketonuria (PKU)

(IRB#: IRB_00155863)

The purpose of this study is to learn more about how the medication called pegvaliase works in people with PKU. This study will help us learn if pegvaliase combined with special Phe-restricted diet (also called a PKU diet) is safe and better than the special Phe-restricted diet alone for controlling blood Phe levels in adolescents.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A Computer Program Designed for Older Adults with Depression

(IRB#: IRB_00103167)

The purpose of this study is to see how well older adults with depression can use a computer program designed to improve certain types of thinking skills (CCR-GD). We also want to learn whether participating in CCR-GD will improve both a persons thinking and mood. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A First-In-Human (FIH) Study of Inhibitory Interneurons (NRTX-1001) in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)

(IRB#: IRB_00157503)

NRTX-1001 is a study drug to help people with drug-resistant mesial temporal lobe epilepsy MTLE. We need to learn the safety and effectiveness of NRTX-1001 for it to be approved by the Federal Drug Administration (FDA) and used to help people with MTLE. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A Health App for People who have Vascular Surgery

(IRB#: IRB_00162534)

The vascular system is made up of vessels that carry blood in the body and lymph (fluid in the body that carries white blood cells to fight infection). Vascular surgery is a way to help people with arterial diseases (narrowing of the blood vessels that reduce blood flow) and venous diseases (veins in the legs do not move enough blood back toward the heart). Such as peripheral vascular disease (PVD) a circulation (how the blood flows through the body) disease. The purpose of the surgery is to improve a persons quality of life, pain, and ability to function. The goal of our research is to see if using a smartphone app helps vascular surgeons and patients track their overall health. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

A Machine Learning Model as an Automatic Tool to Record Human Behavior

(IRB#: IRB_00157027)

A machine learning model may automatically record a human's challenging behavior. Research is needed to learn the value of the model. We want to learn three specific things. 1) How well the model can track challenging behavior? 2) Can the model produce new information based on previous training? 3) How accurate and reliable the model can track challenging behavior based on the new information? The information we gain may aid future patients

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

A new drug combination study in children with Infantile-Onset Pompe Disease

(IRB#: IRB_00147223)

The goal of this study is to see if a new drug combination can help children with Pompe Disease. The two drugs in the combination are called cipaglucosidase alfa (ATB200) and miglustat (AT2221). This study will also see how safe this drug combination is.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A new wearable device for promoting healthy sleeping

(IRB#: IRB_00165943)

The sleep wellness device we are testing produces electromagnetic frequencies that may help relax the brain. It is a wearable band that rests on the back of the neck. This study is testing whether this new device promotes sleep quality for those looking to improve their sleep. We will begin with a baseline week (wearing a fitbit sleep monitor and answering questionniares and a text-message based sleep diary). After baseline, participants will be randomized to wear the device or a placebo for 28 days. In the last week, participants will wear the fitbit again for 7 days and answer questionnaires again to look at how sleep has changed over the 28 day period wearing the sleep wellness device. Only half of the people in this study will have their devices turned on in the active mode. The other half will not have the device on but not in the active mode. This decision will be made randomly and people in the study will not know if their device is on or off. Between 28 days and 3 months, all devices will be activated. Participants can wear the device as much as they would like. We will conduct one more questionniare assessment at 3 months.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

A Program to Promote Resilience in Stroke Survivors and Care Partners

(IRB#: IRB_00142681)

Stroke can have a large impact on a persons life as well as their family. Unfortunately, changes in mood, such as feeling down, anxious, or having difficulty enjoying things, can be a common experience for persons who have had a stroke. Similarly, changes in mood can also affect the persons partner, who provides support. We have created a program for couples who are coping with the effects of stroke. Research is needed to better understand how to design the most effective program that improves the emotional health of couples coping with stroke.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

A Special Program of Recovery for People with Bladder Cancer

(IRB#: IRB_00150155)

People diagnosed with bladder cancer who receive surgery often have some type of malnutrition (eating issue) that can make it harder to recover. A support program has been designed to see if it can reduce dietary problems from bladder cancer surgery. Research is needed to learn if the program improves the quality of life and reduces the risk of malnutrition. We want to know if the program is effective and improves a persons nutrition.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

A Study for Delivering Care to Patients with Refugee Backgrounds

(IRB#: IRB_00167109)

The purpose of this study is to understand barriers that exist when doctors and clinicians (providers) care for people with refugee backgrounds. We also want to learn about experiences that helped providers. The information we learn will allow us to know if more education is needed for providers to serve people with refugee backgrounds. Participants will complete a 3060 minute interview and survey online using a technology device. Participants will receive a $50 gift card after completing the interview and survey. Participants will receive a $15 gift card if only complete a survey.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

A Study for People with Epilepsy

(IRB#: IRB_00146602)

Idiopathic generalizable epilepsy (IGE) is a common form of epilepsy. IGE impacts several million people. This disease can increase risks for other health conditions. Research is needed to better understand what people with newly or established IGE diagnoses need to help them improve their quality of life. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A study in children with Late-Onset Pompe testing Cipaglucosidase Alfa/Miglustat.

(IRB#: IRB_00160440)

This study purpose is to learn if a new drug combination called cipaglucosidase alfa (ATB200) and miglustat (AT2221) can help children with Pompe disease. All children in this study will be treated with these drugs. The treatment will be given every two weeks. Cipaglucosidase alfa is given as an IV infusion. Miglustat is given as an oral pill. Treatment will last for about 52 weeks. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A study in PKU testing JNT517-101

(IRB#: IRB_00168112)

PKU (Phenylketonuria) is caused by a defective gene. When a person with PKU eats foods that contain protein, or eats aspartame, an artificial sweetener, a dangerous buildup of phenylalanine can occur. PTC923 is a study medication to reduce blood Phenylalanine (Phe) levels. This study will assess the safety and how effective this medication is for those of any age with a PKU diagnosis.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A Study of Children and Adults with Tuberous Sclerosis Complex-related Epilepsy

(IRB#: IRB_00150885)

Ganaxolone is a study drug to help children and adults with Tuberous Sclerosis Complex-related (TSC) Epilepsy. Research is needed to learn how safe and effective the study drug is at reducing the number of seizures a child or adult has when added to the current epilepsy treatment and drug(s).

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A Study to Test a Device for People with Blood Clots

(IRB#: IRB_00167854)

The purpose of this study is to learn more about the safety, performance, and clinical benefits of the JETi Hydrodynamic Thrombectomy System. This system is a device used in patients to remove blood clots within a blood vessel. The device is approved by the United States Federal Drug Administration (FDA). Participation in the study will last one year. Participation requires in-person clinic visits at the University of Utah and attending 2 follow-up visits in-person, virtually, or on a phone at the end of the study. Participants are paid $200 at full completion of participation. Participants are paid $200 at full completion of participation.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A Study to Test a Tool to Help People for Anticoagulant Drug-to-Drug Interactions

(IRB#: IRB_00167936)

This study is to better understand the safety of oral anticoagulants (medicine for people taken by mouth to prevent blood clots) which may increase the risk of bleeding events if taken with other medications. Researchers at the University of Utah have developed an app called DDInteract to use on a technology device like a cell phone that allows doctors and patients to make decisions about drug reactions with oral anticoagulants and other medications. We want to see if using the app helps patients and their doctors learn and reduce the risks of taking anticoagulants with other medications. People in this study will participate in a virtual focus group (a discussion together with several people using technology such as a cell phone or computer). The information we gain will help us learn more about the effects of taking oral anticoagulants with other drugs.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

A Study to Test Nasal Swab to Predict If a Lung Nodule is Cancerous

(IRB#: IRB_00168224)

Percepta Nasal Swab Classifier is a genetic tool used to see if the risk of lung cancer is related to finding a lung nodule (unneeded tissue found in the lungs). The tool may be applied at a clinic visit when a person is tested for lung cancer or other medical reasons. The test is done by swabbing inside the nose with a small brush. The study wants to see if the Percepta Nasal Swab Classifier will help doctors and patients know if they are at risk for lung cancer. People in this study will be randomly treated with the Percepta Nasal Swab Classifier. If a person is in the test group, the doctor will receive and share results that may be used in addition to the medical care of a person. If a person is not in the test group, the doctor will not receive results and still provide medical care to assess the risk of lung cancer. Participation in the study is about 2.5 years. Participants will be paid $50 for completing the study visit. The test will be done at an in-person clinic visit.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

A Study to Test Reflexes with Electrical Stimulation

(IRB#: IRB_00166846)

The purpose of this study is to compare reflexes (a muscle reaction in the body) electrically stimulated on the leg or arm and lower back. Electrical stimulation is when a safe stick-on patch is placed above the skin to help reduce pain. We want to see how reflexes change with age, in different muscles and electrically stimulated places. We also want to learn how comfortable the electrical stimulation is on the back by comparing two other different common ways used to treat pain. The study requires a 3.5-hour visit to a University of Utah clinic. During the visit, reflexes will be tested on the leg or arm and back in electrically stimulated places. Participants will be paid $45 for participation. The information we learn will guide us to develop an electrical stimulation method to treat pain and restore movement in the arms and legs.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

A Study to Test the iDOSE Computer Program with the IFX Drug for People with Crohns Disease

(IRB#: IRB_00153856)

Crohns disease (CD) can cause many constant health issues such as severe stomach pain. IFX is a drug to help people with symptoms. iDOSE is a computer program that may guide doctors and patients with CD to know the right amount of IFX to take for better health. Research is needed to learn the effectiveness of using iDOSE. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

ABX464: A Study Drug for People with Active Ulcerative Colitis

(IRB#: IRB_00164026)

Active Ulcerative Colitis is a bowel disease that can cause severe stomach pain and other serious health issues. ABX464 is s study drug for people with this condition. Research is needed to learn the safety and effectiveness of ABX464. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Activities Among People with Physical Disabilities and Their Spouses or Partners Who Provide Caregiving

(IRB#: IRB_00172651)

The quality of the relationship between a caregiver and their care receiver is crucial to the quality of life. The purpose of this study is to learn the effect of how participating in activities together can have on the relationship between someone with physical disabilities and their romantic partner who provides care. People in the study will participate in 20-30-minute interviews.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

Adaptive Cycling for People with Paralysis

(IRB#: IRB_00166092)

This study is to establish a live-cast adaptive spinning program for individuals 18 years and older who have paralysis living outside of Salt Lake County, Utah County, Weber Count, and Davis County. Participate in adaptive spinning twice a week for 60 minutes over 8 weeks from your home. We will loan a cycle for you to participate.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

Adolescent and Young Adults with SCN8A Randomized trial with placebo or NBI-921352

(IRB#: IRB_00150547)

The purpose of this clinical research study is:  to find out if the use of study drug NBI-921352 along with the current therapies you are already receiving can help with the treatment of SCN8A Developmental and Epileptic Encephalopathy Syndrome (SCN8A-DEE) by looking at how it affects things such as your symptoms, quality of life, severity of seizures and frequency of seizures.  to assess the pharmacokinetics (how the body absorbs, distributes, and gets rid of the study drug of NBI-921352 and to determine its effect on the plasma levels of concomitant (other) antiseizure medications and evaluated metabolites.  to evaluate the safety and tolerability of NBI-921352.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Advance Care Planning in Dementia

(IRB#: IRB_00132042)

Advanced care planning is important for adults, but maybe even more for people with memory loss. This disease can leave end-of-life decision-making up to the care partner. Often, the care partner does not know how to make the best decisions in the situation. Research is needed to improve and evaluate a website called LEAD Intervention (Life-Planning in Early Alzheimers and Dementia). LEAD is designed to help persons with memory loss have conversations, document, and share their end-of-life decisions with a care partner, extended family, and healthcare providers.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Age-Friendly Healthcare

(IRB#: IRB_00175251)

Age-Friendly Healthcare provides care for geriatric (for this study, people 65 years and older) patients. The type of care considers what matters most: medication, mentation (mental activity), and mobility (movement). How patients receive care is specific to their needs. This study will help researchers learn how to design and test tools best to support patients and their caregivers (family or friends who help with patient care). People in the study will participate in interviews, surveys, and may wear a Garmin watch to track mobility.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Amniotic Fluid Epidural Injection for People with Low Back and Hip Pain caused by pressure on the Spinal Cord

(IRB#: IRB_00131761)

Lumbosacral radicular pain is in the low back and hip caused by pressure on the spinal cord. The human amniotic fluid epidural injection is a new way to reduce this pain. Corticosteroid dexamethasone is the standard of care to improve symptoms. Research is needed to learn which is more effective at helping people with the condition. The information we learn will aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Assess the Science of Daily Experiences and Quitting Smoking

(IRB#: IRB_00157042)

Tobacco is related to at least 20 different cancers. Most attempts to quit smoking fail. Technology has been developed to better understand how real-time experiences related to a persons identity and emotions impact efforts to quit smoking. Research is needed to assess the support people need to stop smoking. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Assess the Science to Stop Smoking

(IRB#: IRB_00104596)

Tobacco is related to at least 20 different cancers. Most attempts to quit smoking fail. Technology has been developed to better understand how a persons emotions impact people in their efforts. Research is needed to assess the support people need to stop smoking. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Assessing the Presentation and Symptom Burden of Postural Orthostatic Tachycardia Syndrome (POTS)

(IRB#: IRB_00137161)

Postural Orthostatic Tachycardia Syndrome (POTS) is a blood circulation disorder. This study wants to learn more about how to help people with diagnosed POTS or suspected POTS. People in this study will complete surveys. Participation can last about 60 minutes or less. Surveys can be completed using a paper copy at home, electronically, and in person at a clinic visit.

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  • All genders
  • Over 7 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

Asthma & Voice Disorders

(IRB#: IRB_00088230)

Asthma is when a person has difficulty breathing due to swelling or inflamed airways. A voice disorder is when a person may have a problem with speaking due to swelling or inflamed vocal cords. The study wants to learn the effect of taking inhaled medication (medication given to some people with asthma) on people with voice disorders. People in the study will attend visits in person at a study clinic. Medical tests and voice evaluation will be done during the study to track the health of participants.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

Autosomal Dominant Polycystic Kidney Disease Health Information Study

(IRB#: IRB_00142152)

Autosomal Dominant Polycystic Kidney Disease is the most common genetic cause of renal failure (kidneys unable to remove waste and fluid in the body). Autosomal Dominant Polycystic Kidney Disease has been typically known as an adult disease. However, it is becoming known as a disease that begins in childhood. Guidelines for how to help children diagnosed with or at risk for Autosomal Dominant Polycystic Kidney Disease are lacking. The study wants to learn more about Autosomal Dominant Polycystic Kidney Disease and other kidney diseases. The study also wants to expand internet resources so anyone can learn about Autosomal Dominant Polycystic Kidney Disease or other hepato/renal fibrocystic diseases that affect the kidneys. Being in this study does not require attending a visit to a study clinic. Participation does require giving permission for the study team to have access to participants' medical information. Some information that could be collected, would be clinic notes, lab results, and physician consult reports. Participants' names and addresses will be removed from all health information the study team receives.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Avenues for Improving Memory

(IRB#: IRB_00171674)

This study wants to learn the processes of how a persons new movements are learned and remembered. Participants will attend 2 separate in-person visits at the University of Utah. Each visit can last 20 to 40 minutes. Participants will complete a survey and a series of finger tapping tasks on a computer while sounds are played at each visit. Participates will write in a sleep diary 3 nights before the first visit and the night between the 1st and 2nd visit . During the night between the 1st and 2nd visit participants will wear a watch on the wrist to record times of activity and rest. Participants will be paid for their time.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Barriers to Low Back Pain Healthcare for People who are Underserved

(IRB#: IRB_00156672)

Low back pain can require imaging (taking a picture) and other medical needs of the lumbar, (lower part of the back). People may have issues attending appointments for their lower back pain. These include language and translation services and lack of health insurance. The study wants to learn how to better help people attend their appointments for low back pain. Being in the study requires completing a survey. The questions may ask about needing an interpreter, health insurance, childcare, or transportation. People who need health insurance or an interpreter will be given help to attend the appointment. The study team will gather data to learn how to better help participants attend doctor appointments. Information collected will not identify the persons name, address, or phone number.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

BAX 111 rVWF in Pediatrics

(IRB#: IRB_00099444)

The purpose of the study is to look at how well recombinant von Willebrand Factor (rVWF) (the study drug) works to control bleeding that is not caused by surgery. The study will involve children with severe von Willebrand disease (VWD), and we hope to learn how safe the study drug is and how well it is accepted. The study will also look at how safe the study drug is and how well it works during surgery. Finally, the study will look at how childrens bodies process the study drug. This is a Phase 3 study, which means the study drug has already been given to other patients in other studies. In a Phase 3 study the new drug is tested longer and on more people.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Behavioral micro-feature discovery using artificial intelligence

(IRB#: IRB_00135711)

This study uses artificial intelligence technology to discover facial and vocal micro-features in individuals with and without depression.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

BI 706321: A Study Drug for Patients with Crohn's Disease

(IRB#: IRB_00150629)

Crohns disease (CD) can cause severe pain and swelling in a persons stomach. BI 706321 is a study drug to help people with this disease. Research is needed to know the safety and effectiveness of this drug combined with ustekinumab, an approved drug that stops painful symptoms. The information we learn will aid us in understanding how to best treat people with Crohns disease.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Biomarkers in People with Heart Failure and Open-Heart Surgery

(IRB#: IRB_00173355)

Biomarkers are a way for doctors to track a persons health such as blood levels. This study wants to see how biomarkers change with normal heart function compared to those with heart failure. The study will measure blood levels before and after heart surgery with a bypass machine (a heart-lung machine that takes over the heart and lungs during surgery). The study has two purposes. One, help doctors learn the differences in heart failure patients response to surgery. Two, identify patients who may benefit from a different type of blood pressure medication after surgery. People in the study will complete surveys and other medical tests related to heart function before and after heart surgery.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Unpaid

 

Brain Recordings for People with Deep Brain Stimulation for Severe Obsessive-Compulsive Disorder

(IRB#: IRB_00169174)

Obsessive-Compulsive Disorder causes a person to have constant thoughts that can lead to repeated behaviors that may severely disrupt a persons life. This study will look at the effects of deep brain electrical stimulation therapy (small electrodes implanted in a persons brain that send mild amounts of electricity) on a patient with this disorder who has already been implanted with the Deep Brain Stimulation system. The study aims to better understand the relationship between brain activity, behavior, and Obsessive-Compulsive Disorder symptoms to help people with this disorder. People in this study will have the already recorded brain activity they received as standard of care collected and analyzed. Being in the study may last as long as the participant receives stimulation therapy and wants to participate.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Breast Cancer Magnetic Resonance Imaging (MRI) Study

(IRB#: IRB_00114506)

Breast cancer is the second most common cancer for women in America. Magnetic Resonance Imaging (MRI) can be used to see breast cancer. Research is needed to design better imaging techniques for breast cancer imaging. Information we gain may aid future patients.

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  • Female Only
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Building Transition Readiness Skills for Adolescents and Young Adults with Congenital Heart Disease

(IRB#: IRB_00156291)

Congenital heart disease (CHD) is one of the most common birth defects with most major effects diagnosed in infancy. Because there is no cure for CHD it is a lifelong chronic illness. Research is needed to understand the needs of people with CHD as they transition from child to adulthood. This information will improve the care and quality of life for people with CHD.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

C4671026: Study drugs for Children with COVID-19 in Children

(IRB#: IRB_00155069)

Nirmatrelvir and Ritonavir are study drugs for children with COVID-19. These study drugs are only approved by the federal drug administration (FDA) for adults. Research is needed to learn the effectiveness of the study drugs and find the best dose for children with COVID-19.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

CABL001I12201: A Study Drug for Children with Philadelphia Chromosome-Positive Chronic Myeloid Leukemia

(IRB#: IRB_00158588)

Philadelphia chromosome-positive chronic myeloid leukemia is a disease that causes abnormal changes to the chromosomes leading to high levels of abnormal cells in the bone marrow and blood. CABL001I12201 is a study drug for children with this disease. Research is needed to learn the safety and effectiveness of the study drug. The information we gain may aid future patients.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Cancer Stories Shaping Outcomes  Can Your Cellphone Be a Compassionate Listener?

(IRB#: IRB_00143135)

This study is looking at cancer patient voices, actions and body language using computer measurements of behavior via video-recorded answers to questions on your smartphone device using a free app. This research is important because it may help us discover and understand unknown factors that impact cancer treatment outcomes.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

Cannabis (CBD) Effects of Treating People for Chronic Non-Cancer Pain

(IRB#: IRB_00124865)

Cannabis (CBD) is a treatment shown to reduce non-cancer chronic pain. Research is needed to learn more about how CBD impacts brain chemistry. The information learned will help us better understand the effectiveness of CBD for improving the health of people suffering from chronic pain.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

CAP-1002: A Study Drug for Human Allogeneic Cardioshere-Derived Cells for People with Duchenne Muscular Dystrophy (DMD)

(IRB#: IRB_00150933)

Duchenne Muscular Dystrophy (DMD) is a disease that weakens people's muscles over time. CAP-1002 is a study drug to help people with this disease. Research is needed to learn the safety and effectiveness of the drug. This information we gain may aid future patients.

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  • Male Only
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Caracterizar la variabilidad en el funcionamiento ejecutivo y diario en adultos hispanos y latinos mayores (Characterizing Variability in Executive and Daily Functioning in Hispanic and Latino/a/e Older Adults)

(IRB#: IRB_00166063)

Estamos analizando las relaciones entre las habilidades de pensamiento y funcionamiento cotidiano en adultos de habla hispana quienes tienen de 50 años en adelante. Estamos observando el impacto de varios factores diarios, tal como el estado de ánimo, sueño y dolor en la habilidad de pensar y completar tareas todos los días. El estudio implicaría venir a la Universidad de Utah para una consulta de investigación de 4 horas y luego hacer tareas diarias en su casa por las siguientes 3 semanas. ¡Le pagaremos su participación! No tiene que tener número de seguro social para participar. Comuníquese con nosotros para más información si está interesado y cumple con el criterio del estudio. (We are examining the relationship between thinking skills and daily functioning in Spanish-speaking adults who are 50 and older. We are looking at the impact of many daily life factors, such as mood, sleep, and pain, on your ability to think and get tasks done each day. The study will involve coming to the University of Utah for a 4-hour research visit and then doing daily tasks at home for the following 3 weeks. We will pay you for your participation! You do not need to have a social security number to participate. Please contact us for more information if you are interested and meet the study criteria.)

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Caregiver burden associated with Rotavirus-gastroenteritis in the United States

(IRB#: IRB_00148762)

You and your child are being invited to participate in this observational research study. Your participation is voluntary. An observational study is research that aims to collect data over time on how a certain treatment is used and its effects, without any change to your normal care. This means that routine clinical practice is followed. Any treatment given follows your normal routine and is decided by you and your doctor. This study will not alter or interfere with the normal care you receive in any way.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

Caregivers' Emotions to Their Young Children Related to Stress

(IRB#: IRB_00165890)

This study is to better understand families' experiences with their young children. We want to know about the emotions that caregivers show to their children and how these are related to caregivers' stress levels. This will help us better support families and their young children. People in this study will complete surveys on an iPad or phone for 14 days for one month. Compensation is provided for the completion of surveys. Participant names are not identified. What we learn will help us better understand how caregivers stress and emotions are expressed to their children.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Cervical Medial Branch Radiofrequency Ablation (CMBRFA) compared to Trident Multi-tined Cannula for People with Cervical Facet Pain

(IRB#: IRB_00143800)

Cervical facet pain is an arthritis-like joint pain that can be chronic and occur in the back and neck of the spine. Cervical medial branch radiofrequency ablation (CMBRFA) is an effective treatment for this health issue. Trident Multi-tined Cannula is also a way to help people with cervical pain. Research is needed to learn the characteristics and effectiveness of Trident Multi-tined Cannula compared to CMBRFA. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Changes in voice tremor in those with essential tremor treated with focused ultrasound

(IRB#: IRB_00164533)

Essential tremor is when a part of a persons body such as a hand or arm is unsteady or shaky. Vocal tremor is when people may experience an unsteady or shaky voice. This condition may impact the mouth and throat muscles. This study will test whether people receiving focused ultrasound for treatment of essential tremor show improved voice tremor. People in this study will answer questionnaires and be observed for tremor in the face, jaw, tongue, and throat as well as using audio recordings and participant self-reporting. For those who are willing, the study will also examine the speech structures affected by tremors using nasoendoscopy (a procedure to look inside the throat and nose). Participation in the study requires some visits to a study clinic and completion of other activities will be done over the phone and online to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Children and Adults with Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)

(IRB#: IRB_00113124)

EoE, EG, and EC are digestive diseases. Research is needed for us to understand the relationship of EoE, EG, and EC with mucosal eosinophilia, severe stomach, and bowel pain, in children and adults. The information we learn will help us find better ways to provide care for children and adults with these diseases.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Chronic Non-Cancer pain MRI research study evaluating the effects of oral cannabis on chronic pain

(IRB#: IRB_00103451)

The purpose of the study is to evaluate the effects of two substances derived from cannabis (THC and CBD) in participants with chronic non-cancer pain compared with a placebo. The study drug will be administered as an extract mixed in chocolate pudding. Participants will be allowed to stay on their current pain treatments for the study but may not add any more medications during the study. Participation in this study will be confidential. This study has been approved by the FDA, DEA, and University of Utah IRB.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Circadian Timing and Chronic Disease

(IRB#: IRB_00159535)

Circadian timing is when a person's daily behaviors occur such as eating and sleeping. Circadian timing may affect a persons health and well-being. Research is needed to learn if improving circadian timing impacts body metabolism (how a person processes and uses food). Which may lead to chronic diseases such as diabetes and heart disease. The research we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

College Singing Teachers Use of Vocalises

(IRB#: IRB_00164530)

Vocalise is when a person sings without words. This skill may be used to teach people how to sing. In the past, singing teachers have taught students using vocalises. Today, these may not be used to teach students. Research is needed to learn how past vocialises can be used to teach college students to sing.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

Comparing COVID-19 Boosters for Protection Against the SARS-CoV-2 Virus

(IRB#: IRB_00172738)

This study is to understand better whether and how well COVID-19 booster vaccines protect people from the SARS-CoV-2 virus. The information we gain will help us learn more about how to provide people with better protection against this virus. People in this study will complete online surveys and take at-home COVID-19 tests. Two groups are in the study, and people can choose the group they want to participate. One group does not receive the COVID-19 vaccine, and the other does receive the COVID-19 vaccine. Compensation up to $550 is provided for the completion of study activities.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Connecting Online Peers to Support Adults with Type 1 diabetes

(IRB#: IRB_00153324)

Diabetes is a serious disease for millions of Americans. Self-management of the condition can be difficult. Social support shows people better manage the disease by working with peers. Connecting online peers is a way to help people with the disease. Research is needed to compare the effectiveness of online peer support groups for young adults with type 1 diabetes.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Consumer Decision Making

(IRB#: IRB_00136063)

This study is designed to understand the day-to-day decisions made by consumers.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Consumer Financial Decision Making

(IRB#: IRB_00172376)

Consumer financial decision-making is when and how a person decides to spend money on purchases such as housing and food. This study will help to better understand when and how people make daily decisions about spending money including using credit cards. People in the study will be randomly assigned into groups. Participants may be asked to think about spending money, choosing how to make purchases, and making purchases. Participants will be asked to share and write their thoughts about consumer financial decision-making and complete surveys.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Continuous Glucose Monitoring in Adults with Diabetes and Cognitive Impairment or Dementia and Their Care Partners

(IRB#: IRB_00172781)

Continuous Glucose Monitoring is a way to show people with diabetes when they have high or low blood sugar throughout the day. Continuous Glucose Monitoring data can be shared continuously with care partners (family or friends) using an app. However, the person with diabetes and their care partner may need help communicating and problem-solving using the sugar data. This study will explore how to change a current program that uses this data-sharing app. The new program will help older adults with diabetes and cognitive impairment (hard to remember or learn new things), or dementia (memory loss) and their care partners share Continuous Glucose Monitoring data. People in the study will complete a survey and attend a 30-to-90-minute discussion with about 5 to 8 other people to give researchers advice on how to change a current Continuous Glucose Monitoring program. People will be paid for participating.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Continuous Glucose Monitoring with Data Sharing in Older Adults with Type 1 Diabetes and Their Care Partners

(IRB#: IRB_00160673)

The purpose of this study is to learn if a new phone app for data sharing helps older adults with type 1 diabetes and their care partners better monitor glucose levels. Research is needed to improve how people with diabetes and their care partners communicate, problem-solve, and develop action plans around data sharing glucose data. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Couples, healthy aging, rhythms and sleep study (CHARMS)

(IRB#: IRB_00158095)

As people get older they are more likely to have changes to their bodys rhythms, like waking up too early or in the middle of the night. As people get older, their sleep quality also goes down. We also know that sleep in one partner can affect the sleep of the other. Research is showing that having regular sleep/wake rhythms and good quality sleep can help your memory as you get older. The goal of this study is to understand how sleep in couples affects each others sleep and memory over a 2-year period.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

CSL-964

(IRB#: IRB_00125273)

A study to evaluate the safety and efficacy of Alpha 1 Antitrypsin for the prevention of graft versus host disease in patients receiving hematopoietic cell transplant

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Cuffless Blood Pressure Study in Patients with Cardiovascular Conditions

(IRB#: IRB_00170063)

This study aims to test bioimpedance technology to measure blood pressure in patients. Normally people measure their blood pressure with an inflatable cuff on their arm. Bioimpedance technology involves placing sensors in the skin for non invasive recordings. People in this study will wear this new device at the Heart Failure Clinic at the University of Utah Medical Center. These will help us get more measurements to see if the technology works. The study session will last about 30 minutes.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

CVL- 865: A study drug for people with drug-resistant Focal Onset Seizures

(IRB#: IRB_00166301)

This study is open to participants who were in the previous seizure trial numbered CVL-865-SZ-001. This study will give these previous participants open-label treatment with the study drug for 57 weeks. The study drug is called CVL- 865.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Decision-Making of People with Cancer

(IRB#: IRB_00131189)

This study will identify patient and caregiver needs when making decisions with their medical team about continuing or stopping anti-cancer therapy. The study also wants to explore patients thoughts and ways used to share information about the diagnosis of cancer. People in this study will participate in a 2-hour online focus group with 9 other participants and/or a private 1-hour interview. Conversations and all contact information will be confidential. Those who participate in the focus group will receive $65. Those who participate in an interview will receive $35.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Delayed Orthostatic Hypotension in Individuals with Parkinson's Disease

(IRB#: IRB_00170338)

A persons autonomic nervous system is the part of the nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of the blood vessels. Parkinson's disease can cause dysfunction of the autonomic nervous system causing orthostatic hypotension which is a form of low blood pressure that happens when you stand up from sitting or lying down. Orthostatic hypotension can make a person feel dizzy or lightheaded and may even cause fainting. Delayed orthostatic hypotension describes a drop of blood pressure happening beyond 3 minutes of standing. The purpose of this study is to learn the frequency and risk factors of delayed orthostatic hypotension in people with Parkinsons disease. The information will help clinicians be better aware of providing care to patients with delayed Orthostatic hypotension. People in the study will have their blood pressure and heart rate measured. There will be only one 20-minute study visit to measure these.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

DNL310: A Study Drug for Children and Adolescents with Hunter Syndrome

(IRB#: IRB_00157640)

Hunter syndrome is a disease that may cause delays in cognitive (part of the brain) development and disruptive and impaired behaviors in children and adolescents. DNL310 is a study drug for children and adolescents with Hunter Syndrome. Research is needed to learn the safety and effectiveness of DNL310. The information we gain may aid future patients.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

DTX301-CL301: Gene Therapy for Late-onset Ornithine Transcarbamylase Deficiency (OTC deficiency)

(IRB#: IRB_00150121)

Ornithine Tanscarbamylase Deficiency (OTC deficiency) is an inherited disorder that causes toxic levels in the blood. The disease increases the risk of mental health problems and other health issues. DTX301-CL301 is a study drug used for gene therapy. Research is needed to learn the safety and effectiveness of the treatment. The information we gain may aid future patients.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Dual-Tracer Theranostic Position Emission Tomography (PET)

(IRB#: IRB_00158172)

Position Emission Tomography (PET) /CT scans are a way to see images inside of the body. Theranostics are a combination of using a radioactive drug to diagnose and a second radioactive drug to deliver therapy. Research is needed to develop methods that combine 2 different types of scans. These may be given to patients with neuroendocrine tumors and prostate cancer. The goal of the study is to eliminate the need to have the scans given separately and combine them into one patient health clinic visit.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Early Detection of Lung Cancer based on small RNA signatures (Boston II)

(IRB#: IRB_00166058)

This study will see if a new test can diagnose lung cancer. The new test is called the HBDx small RNA diagnostic test for lung cancer. People in this study will participate for 12 months. You will give blood at one clinic visit at the start of the study. This blood will be used to run the new test. We will collect information from your medical record for 12 months after the visit. At the end of 12 months, we will contact you to ask about any imaging, biopsies or surgical procedures you might have had at another healthcare facility.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Efzofitimod: A Study Drug for People with Pulmonary Sarcoidosis

(IRB#: IRB_00156634)

Pulmonary Sarcoidosis is a disease that most commonly affects the lungs and causes other health conditions that impact a persons quality of life. Efzofitimod is a study drug to help people with this disease. Research is needed to learn the safety and effectiveness of the drug. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Elucidating Brainstem Contributions to Visceral and Somatic Motor Dysfunction after mTBI

(IRB#: IRB_00135817)

Optimal rehabilitative care following mild traumatic brain injury (mTBI) should be based on approaches that target the key underlying mechanism of dysfunction. However, the underpinnings of motor problems after mTBI, including imbalance and improper regulation of heart rate and blood pressure, remain unclear. This project will use state-of-the-art neuroimaging methods and detailed testing of motor function to examine the role of the brainstem in motor problems to better guide care in people with mTBI. Participants will have an MRI brain scan and complete several tests of mobility, cardiovascular, and pupillary function at two visits, separated three months apart.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Emotion Regulation and Depression in Older Adults

(IRB#: IRB_00109640)

Emotional regulation (ER) may be how a person behaves in social settings and in decision-making. Most ER research is from young adults. We want to learn about ER in older adults and the impact of depression. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Emotional Awareness and Expression Therapy (EAET): A Study Treatment for People Living with Migraine

(IRB#: IRB_00164970)

Migraine headaches are a severe health problem. Though there is current medication and ways to help people with migraine, most still have issues. A persons level of stress and past traumatic experiences may cause migraine. Emotional Awareness and Expression Therapy (EAET) is a new way to help people manage emotions. We want to know how effective EAET is at reducing migraine. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Eosinophilic Esophagitis Dietary Effects

(IRB#: IRB_00149437)

Eosinophilic Esophagitis is a disease that often causes allergic reactions to types of food. When patients with this disease eat certain foods, they may have trouble swallowing and get food stuck in their esophagus. Over time, scarring and narrowing of the esophagus can occur. Currently, the only way for patients to identify the types of food that trigger the disease is to eliminate foods from the diet. This requires endoscopy with biopsies every 6-8 weeks after each diet change. Research is needed to develop a better way to diagnose and improve the health of people with Eosinophilic Esophagitis disease.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

EsoCheck a Tool to Find Barretts Esophagus (BE)

(IRB#: IRB_00131631)

Barretts Esophagus (BE) is when a person's tube connecting the throat to the stomach is damaged from stomach acid. BE causes cells to grow which can cause cancer in the esophagus. EsoCheck is a tool that collects cells. The cells are put into EsoGuard to see if a person has BE. Research is needed for us to understand the effects of using EsoCheck and EsoGuard together. The information we learn will help us know if this works as well or is better than what is done now to find if a person has BE.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Evaluating Real-World Use of CDPATH, a Crohns Disease Risk Prediction Tool

(IRB#: IRB_00151739)

The primary objective of the study is to explore the use of a CD risk prediction tool (i.e., CDPATH) to describe the risk profiles of patients with CD in real-world practice.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Evaluation of Sensory Tricks in Individuals with Laryngeal Dystonia or Essential Vocal Tremor

(IRB#: IRB_00130977)

Laryngeal dystonia (LD) is a rare neurogenic voice disorder that results in an intermittently strained-strangled or breathy voice quality during speaking. Essential tremor of the voice (ETv) is another neurogenic voice disorder typically perceived as a shaky voice quality but sometimes associated with a similar voice quality to LD, making it challenging for clinicians to distinguish these voice disorders. A correct diagnosis is essential for accurate and effective treatment of these voice disorders. However, clinical voice experts often confuse these disorders and frequently disagree with each other when judging voice quality or observing speech structures. Development of clinical tools that help clinicians make the correct diagnosis of these disorders is a priority. Therefore, we propose studying a characteristic of dystonias, sensory tricks. A sensory trick is a phenomenon diagnostic of dystonias described as a short-term improvement of symptoms due to sensory cues like touching or supporting a body part or being distracted by a sound. This phenomenon is well studied in other kinds of dystonia but has not been systematically evaluated in LD. This pilot study aims to evaluate whether sensory tricks improve voice symptoms in those with LD compared to those with ETv. If successful, outcomes will help identify specific sensory trick(s) that most clearly change LD symptoms and show promise for improving correct diagnosis of those with LD. The sensory tricks studied should be accessible and affordable for use during assessment by clinicians to help distinguish those with LD from ETv. Importantly, findings will inform future studies to improve utilization by clinicians.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Evaluation of the HAPPIEST program - a collaborative team summer research program

(IRB#: IRB_00144170)

The overall goal of this project is to evaluate the training program at University of Utah of undergraduate students from underrepresented racial/ethnic backgrounds in air pollution-related health research through a faculty-mentored summer program called Health, Air Pollution and Population Initiative in Education and Science Training (HAPPIEST). Since exposure to air pollution and environmental health issues are magnified in racial/ethnic minority communities in the US, this project addresses an important need in biomedical science training for the next generation, as social disparities and the socio-behavioral sciences are becoming increasingly important to health scholarship as well as US national priorities.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Unpaid

 

Exercise and Brain Function

(IRB#: IRB_00152596)

Exercise is known for helping a persons brain function. Research is needed to better understand how exercise may help improve the brain's learning and memory processes. The information we gain may aid future patients.

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  • Male Only
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Factors of Mental Health and Social Influence

(IRB#: IRB_00167428)

This study wants to learn more about how a person's social and identity influence mental health. These include attitudes, opinions, decision-making, and finding help. Participants in this study will take a survey. The survey is about everyday life experiences and ideas about mental health. These include decision-making, seeking help, social influence, and identity. The survey will be done online with technology such as a computer or cell phone. The survey will take about 30 minutes.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

Ferric Citrate: A Study Drug for Children and Teenagers with Hyperphosphatemia from Chronic Kidney Disease

(IRB#: IRB_00161276)

Chronic Kidney disease can cause Hyperphosphatemia (extra phosphate in the blood). Ferric Citrate is a study drug for children and teenagers with this condition. We are trying to find out if the study drug can safely lower the amount of phosphate in the blood of children and teenagers. The information we gain may aid future patients.

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  • All genders
  • 7 to 17 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

FIREFLY-1

(IRB#: IRB_00138633)

The description and purpose of the study drug is to research the use of an investigational product labeled NA- IP (DAY 101- formerly TAK-580/MLN2480) to treat Low-Grade Glioma and other advanced solid tumors in pediatric and age-of-majority participants

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Hair Chemicals in Children with Autism Spectrum Disorder

(IRB#: IRB_00153961)

Chemicals applied to a childs hair may impact health outcomes, especially for children with an autism spectrum disorder. Research is needed to learn how chemicals in these children's hair such as zinc, copper, and lead affect health. We also want to know if finding these chemicals in hair is a way to detect autism disorder sooner. The information we gain may aid future patients.

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  • All genders
  • Under 7 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

HCI-Total Cancer Care Study

(IRB#: IRB_00089989)

This study is a partnership between participants, health care providers, and researchers. Our aim is to better understand what causes cancer and to find better ways to prevent, detect, and treat cancer more successfully while also supporting your family. This study is an opportunity to contribute samples and information that will be used to accelerate cancer research and improve patient care. Participants like you are vital to our success. The study also offers access to a broader set of clinical trials and new treatments through our partnership with other leading cancer centers nationally. There is no cost to be in this study. No matter what you decide, it won't change the relationship with your health care providers to affect the quality of your care.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

HEALEY ALS Trial

(IRB#: IRB_00143448)

This study is looking at the safety and effectiveness of four different investigational treatment regimens: Zilucoplan, Verdiperstat, CNM-Au8, and Pridopidine for ALS. Each regimen will have an active investigational product and a matching placebo that will be tested. New regimens will be continuously added as new investigational products become available.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Health and Safety Consequences of Poor Sleep Health

(IRB#: IRB_00133959)

Sleep is a key factor affecting your overall health. We want to investigate if altering your nightly sleep duration impacts your bodys metabolism (how you metabolize food). We will also look at your physical activity, food intake, and cognition during the study.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Hearing Effects in Children with CMV

(IRB#: IRB_00151251)

Cytomegalovirus (CMV) is a virus that can occur in babies ages 0-4yrs old and may cause hearing loss. Research is needed to learn more about hearing loss and its effect on language development. The information will help us understand the best types of care that improve the health of children with CMV.

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  • All genders
  • Under 7 years old
  • Healthy Volunteers
  •   From Home
  • Unpaid

 

Heart Health among Utah People of South Asian Ethnicity

(IRB#: IRB_00162801)

People of South Asian ethnicity are at higher risk of heart disease than people of other ethnicities. Locally, these community members have met and want to reduce the issue. To do this we design health screening events for people of South Asian ethnicity to attend and learn if they are at higher risk for heart disease. If so, we have an opportunity to participate in a research study that may help improve heart health.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Home- and Community-Based Services for Veterans with Cognitive Impairments and their Caregivers

(IRB#: IRB_00152365)

Veterans are at a high risk of having Alzheimer's disease and related dementias (AD/ADRD). This is because of military experiences like traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Family members often provide care for Veterans with AD/ADRD. This allows them to live at home in their community. Research is needed to learn about these Veterans and caregivers' current needs and the best home- and community-based care services. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

How COVID-19 has Impacted Secondary School Aged Students with Autism

(IRB#: IRB_00135759)

The purpose of this study is to explore the academic, psychological and social experiences of secondary school aged individuals with an autism spectrum disorder during COVID-19.

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  • All genders
  • Over 7 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

How do children listen in complicated auditory environments?

(IRB#: IRB_00126429)

Children have more difficulty listening in complex environments like a classroom than adults. Children with hearing loss experience even more difficulty than children without hearing loss. Scientists and doctors do not fully understand the characteristics of the environment and the listener that makes listening difficult. Research is needed to design better methods that improve the health of people with listening challenges in complex environments.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

How does brain function change during a treatment cycle of Botox injections for the voice disorder adductor laryngeal dystonia?

(IRB#: IRB_00143531)

The purpose of this study is to find the locations in the brain that are affected by Botox injections into the throat muscles in patients who have adductor-type laryngeal dystonia (also known as adductor spasmodic dysphonia). Participation in this study involves brain scans along with assessments of the voice muscles. Brain scans involve 1) laying still in a scanner while resting and speaking and 2) wearing a head cap while seated and reclined during speaking tasks. Assessment of voice muscles involves small needles inserted into muscles in the voice box. All procedures are well-tolerated by most people. Participants with laryngeal dystonia will have 4 brain scans (2 of each kind) and 2 voice muscle assessments over 1 Botox cycle (approximately 3-4 months). A second purpose of this study is to evaluate a specialized speech therapy program for treating laryngeal dystonia. Therapy will take place over 6 months (2 Botox cycles) and will incorporate in-person or virtual session along with home practice. Some participants may be eligible to participate by completing only some portions of the study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

How does kidney blood flow affect heart failure?

(IRB#: IRB_00154546)

We want to learn how blood flow in the kidneys might affect heart failure. We will test some people with normal heart function and some with stable heart failure. We will also test some people with diabetes. The tests are a blood test, a urine test, an MRI, an echocardiogram, and an ultrasound. We will also collect information about the medications you take and other medical problems you might have.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

How Meditation Reduces Chronic Low Back Pain and Opioid Use By Changing the Brain

(IRB#: IRB_00133405)

We are comparing two different forms of meditation-based group therapy versus usual care for people taking opioids to alleviate chronic low back pain. In this study, you may be randomly selected to participate in one of two different forms of meditation-based group therapy (8 weekly sessions), or to continue with your usual low back pain care. You will participate in a pain challenge where you have your brain scanned while you practice meditation to reduce discomfort caused by heat delivered by a safe scientific instrument. You will be compensated for your participation.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Identifying Deceased American Service Members; Prisoners of War (POW) and Missing in Action (MIA)

(IRB#: IRB_00139648)

This study is collecting a persons wisdom teeth/third molars (teeth located near the back of the mouth) from people across the United States. The study team will use the teeth to learn more about the life history of people from different places in the country. The information may help identify American military prisoners of war and missing in action.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Improve Magnetic Resonance (MR) Imaging for a Peoples Diagnosis and Therapy

(IRB#: IRB_00076123)

The purpose of the study is to learn if new hardware and/or software for Magnetic Resonance Imagining (MRI) helps doctors better see into a persons body with or without diseases. Research is needed to improve the quality of pictures and shorten a person's scanning time. Including the length of stay in the magnet (the machine where a person is scanned). The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Improve Technology to Rehabilitate People with Non-Mobility and Mobility Impairment

(IRB#: IRB_00160259)

Smart Technology may be used to help rehabilitate people from injuries. Technology can measure a persons movements such as how they walk. There is a new technology that might reduce the cost and amount of time required to recover from an injury. Research is needed to see if the new technology improves rehabilitation for adults with non-mobility and mobility.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Improving Assessment of Executive Functioning in Culturally Diverse Older Adults

(IRB#: IRB_00145891)

Neuropsychological evaluations are often used to help doctors determine how well an individual can live independently. However, many of the tests neuropsychologists use were developed on non-Hispanic White individuals and are not as accurate in culturally diverse individuals. The goal of this study is to determine which measures are best for assessing functioning in culturally-diverse individuals so that neuropsychologists have a better understanding of how improve the accuracy of their assessments.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Improving Care for Children Who Have Kidney Transplants Due to Kidney Disease

(IRB#: IRB_00138538)

Kidney disease is when blood in the body is not filtered creating extra fluid that can cause serious health issues such as heart disease or stroke. The study wants to see how to improve care for children who have kidney transplants (a surgery that removes an unhealthy kidney and replaces it with a healthy kidney). Improving Renal Outcomes Collaborative is a network of patients, families, caregivers, and researchers that provide data to find better ways to care for children with kidney transplants. Participants in the study will share health data to be collected into a secure database to develop new methods that improve care for children with kidney transplants.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

Improving Congenital Heart Disease Care for Adolescents and Young Adults

(IRB#: IRB_00149991)

Congenital Heart disease (CHD) is one of the most common birth defects with most major effects diagnosed in infancy. Because there is no cure for CHD it is a lifelong chronic illness. Research is needed to understand the needs of people with CHD as they transition from child to adulthood. This information will improve the care and quality of life for people with CHD.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Improving Corneal Ulcer Outcomes

(IRB#: IRB_00155406)

Undiagnosed corneal infection leads to blindness. Research is needed to develop a new testing method for finding types of corneal ulcers to stop the risk of blindness. The information we gain may aid future patients.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Improving Health Insurance Literacy for Young Adult Cancer Survivors

(IRB#: IRB_00164028)

Health insurance can be difficult for young adults with cancer to find answers to questions about their health insurance plan. This studys purpose is to help young adult cancer survivors understand their health insurance and costs. People in this study are required to complete 3 online surveys over 12 months. Each survey will take about 20 minutes. Participants will be paid for completing each activity. Some participants will receive a digital informational booklet about health insurance while other participants will receive this booklet and also complete 4 health insurance support sessions with a navigator. Sessions will be completed on Zoom and last about 45 minutes.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Improving Mental Health Therapy Inequities and Disparities

(IRB#: IRB_00149225)

Racism is a fundamental cause of health inequities and disparities that severely impact the health of Americans. Research is needed to better understand mental health therapists anti-racist practices with people who identify their race as white. The information learned will help design more equitable strategies for people receiving mental health therapy.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Improving MRI for People with Heart Disease

(IRB#: IRB_00154019)

People with heart disease may need an imagining scan known as an MRI. Research is needed to improve MRI methods used for finding heart problems and better determining what is normal and what is a disease. These include myocardial fibrosis. The thickening of tissue in heart muscles. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Improving your blood pressure through culinary medicine

(IRB#: IRB_00145096)

High blood pressure is a silent disease that can have devastating consequences. Keeping your blood pressure under control will reduce your risk of developing heart disease, strokes, and even dementia. This study is designed to help you accurately detect if you have high blood pressure, and then get you the treatment you need to keep it under control. In the intervention arm, you will get to participate in a series of cooking classes and learn how to cook foods which will improve your blood pressure without the use of medications. We will discuss components of the DASH diet and teach key culinary skills to help you feel confident preparing and eating more healthful food. If you choose to participate, you will be asked to attend all physician visits, nurse visits, and shared medical visits. You will also be asked to track your blood pressure at home and report it every few weeks to few months. You will be asked to get labs, and weight periodically as well to track your health.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Unpaid

 

Impulsiveness and Suicide of Young Adults with Bipolar Disorder

(IRB#: IRB_00137442)

Bipolar disorder may increase suicide risk, especially in young adults. Impulsiveness and suicidal thoughts can create a higher risk and make it harder to control thoughts of suicide. Research is needed to learn how bipolar disorder may be connected to impulsiveness and suicidal thoughts. The information we gain may aid future patients.

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  • All genders
  • 7 to 17 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Inflammation as People Age

(IRB#: IRB_00153158)

As a person gets older, immune cells in your blood can create inflammation causing swelling and pain in the body. Research is needed to learn the health and effects of these cells. The information we learn in this study will help us design better ways to aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Inhaled Treprostinil: A Study Drug for People with Idiopathic Pulmonary Fibrosis (IPF)

(IRB#: IRB_00162671)

Idiopathic Pulmonary Fibrosis (IPF) is a rare illness that severally affects the lungs making it hard to breathe. Inhaled Treprostinil is a study drug for people with IPF. The medicine is given by breathing into the lungs using a machine called a nebulizer (breathing device). The machine turns the medicine into a mist to breathe into your lungs. Research is needed to learn the safety and effectiveness of the drug and provide or continue to provide inhaled Treprostinil for people previously in the RIN-PF-301 (TETON) study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Intergenerational Differences in Mental Health within South-Asian Households

(IRB#: IRB_00173613)

Intergenerational (people of many ages) differences may have mental health perspectives differ from parent to child. This study will explore how intergenerational mental health views differ from parent to child. Including the effects of family dynamics and the personal mental health of family members. Specifically, in homes with South-Asian immigrant parents and their second-generation children. People in the study will complete surveys and interviews.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

INZ-701: A Study Drug for Infants with Generalized Arterial Calcification of Infancy (GACI) due to ENPP1 Deficiency

(IRB#: IRB_00158538)

Generalized Arterial Calcification of Infancy (GACI) is a rare genetic disease that causes calcium buildup in the blood vessels throughout the body. This calcium buildup narrow these blood vessels, and especially the arteries, which often leads to high blood pressure, heart disease, strokes, and kidney disease. One of the main genetic causes of GACI is the lack of an enzyme called ENPP1. INZ-701, is a study drug to help infants with this ENPP1 Deficiency. Research is needed to learn the safety and effectiveness of INZ-701. The information we gain may aid future patients. INZ-701 is a medication given under the skin. In this study, participants would receive study medication at least once a week. Study visits are in person and weekly for the first month and then every 4 weeks.

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  • All genders
  • Under 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

IONIS: A Study Drug to Improve Symptoms of FUS-ALS Patients

(IRB#: IRB_00144685)

IONIS is a potential drug to reduce the body's production of the FUS protein that may contribute to ALS. Scientists and doctors need to learn the effectiveness, safety, tolerability, and breakdown of this medication to improve the symptoms of people with ALS.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

JR-141 infusion in MPS II (Hunter Syndrome)

(IRB#: IRB_00162681)

Hunter syndrome is a disease that may cause delays in cognitive (part of the brain) development and disruptive and impaired behaviors. JR-141 is a study drug for people with Hunter Syndrome. Research is needed to learn the safety and effectiveness of JR-141. The information we gain may aid future patients.

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  • Male Only
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Lanifibranor in adult patients with non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2 (F2)/fibrosis 3 (F3) stage of liver fibrosis

(IRB#: IRB_00145070)

This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis stage 2 or 3 and consists of 2 sequential parts, Part 1 and Part 2, with the following primary objectives and primary endpoint for the definition of treatment effects.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Laser Evoked Potentials (LEP) in Patients with Low Back Pain and Healthy Volunteers

(IRB#: IRB_00158608)

People with low back pain may need testing for diagnoses and treatment evaluations. Research is needed to assess if more quantitative measures such as laser evoked potential (LEP) and quantitative sensory testing can be used to tease out differences in patients with low back pain problems and better determine the treatment outcomes. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

LAU-7b: A Study Drug for People Hospitalized with COVID-19

(IRB#: IRB_00152353)

Peoples health with COVID-19 and other medical issues such as high blood pressure or existing lung disease may get worse over time and might need to go to the Intensive Care Unit. LAU-7b is a study drug for people with COVID-19 that also have other medical issues. Research is needed to know if the drug is safe and effective to improve peoples health. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Learning and Memory

(IRB#: IRB_00155080)

Building new memories is known to be a long process. However, studies do show new information can be gained quicker if combined with previous knowledge. Research is needed to learn if young healthy adults build memory faster by attaching present experiences with the past. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Learning New Movements Across the Lifespan

(IRB#: IRB_00136894)

The goal of this research is to provide a comprehensive investigation into how novel movements are learned and subsequently stored into long-term memory across the human lifespan.

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  • All genders
  • Over 7 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Liver Transplantation in Patients with Cirrhosis and Severe Acute-on-Chronic Liver Failure (ACLF)

(IRB#: IRB_00142539)

Cirrhosis is a disease that causes scar tissue to form in the liver. ACLF is a chronic liver disease that causes liver failure. Research is needed to better understand how people respond to liver transplantation with the combination of these conditions. The information we learn will help us improve the care of people with Cirrhosis and Severe Acute-on-Chronic liver disease.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Long-Term Follow-Up of Patients Who Received Lentiviral-Based CAR-T Cell Therapy

(IRB#: IRB_00079262)

People with specific types of cancer such as leukemia and lymphomas may receive Lentiviral-Based CAR-T Cell Therapy. This is to help improve the symptoms of this disease. Research is needed to learn the long-term safety and effectiveness of the therapy. The information we gain may provide further guidance to patients, doctors, and researchers.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Magnetic Resonance Imaging (MRI) in Atherosclerotic Disease of the Carotid Artery

(IRB#: IRB_00143315)

Atherosclerotic Disease is a buildup of fat, cholesterol, and other substances on artery walls. An MRI is a way to see places that may have buildup. Research is needed to improve the way an MRI automatically and accurately sees inside the artery walls. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

MAINTAIN YOUR WEIGHT STUDY

(IRB#: IRB_00132802)

If you have intentionally lost at least 5% of your highest weight in the last 2 years, you may qualify for a study that provides coaching to support you in maintaining your healthy habits & weight loss. The coaching will be provided to participants at no cost.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Massage and the Brain

(IRB#: IRB_00155218)

In 2018, over 47.5 million adult Americans received at least one massage. Although massage is commonly used to improve overall health and symptoms of depression and anxiety, the effects on the brain are unclear. This study will use fMRI, an image taken to show how the brain responds to whole-body massage. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Massage for Generalized Anxiety Disorder (GAD)

(IRB#: IRB_00153327)

Generalized Anxiety Disorder (GAD) is very upsetting and disabling for people. Massage is known to decrease anxiety. Research is needed to study the effects massage has on symptoms of anxiety and the brain. The information we learn will improve our knowledge of massage to provide more options of care for people with GAD.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Measuring Language Between People with Aphasia and Neurotypical Adults

(IRB#: IRB_00149485)

The study's purpose is to measure event-related potentials (ERPs) of people with aphasia or neurotypical adults. Aphasia is when a person may be unable to speak well after a brain injury such as a stroke and head trauma. Neurotypical is when a person has standard brain functions such as the ability to speak or write without much effort. An ERP is a brain response to when a person may feel, think, speak, write, and move. An ERP is measured through an electromagnetic encephalogram (EEG). An EEG is a cap worn on top of the head with electrodes attached to the cap. The electrodes are a safe way to allow a small amount of electricity to measure a persons brain activity. Participants will read sentences while having their brain activity measured with an EEG. This study will help us better understand language challenges and develop effective ways of language recovery for people with aphasia. Participants will receive $10 an hour for in-person participation at a University of Utah clinic or online using a computer or phone.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

MEDI3506: A Study Drug for People who had Chronic Obstruction Pulmonary Disease (COPD) with a History of Severe COPD

(IRB#: IRB_00153167)

Chronic Obstruction Pulmonary Disease (COPD) is a type of progressive lung disease with symptoms such as difficulty breathing. MEDI3506 is a study drug to help people with COPD. Research is needed to learn the safety and effectiveness of the drug. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Metformin for People with Fibromyalgia Symptoms

(IRB#: IRB_00160543)

Fibromyalgia may cause people serious chronic pain. It is very difficult to help people with this pain. Metformin is an approved drug. Research is needed to learn if metformin helps people with pain from fibromyalgia. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Migraine Progression and Prevention

(IRB#: IRB_00161605)

Migraines progress becoming more severe or frequent. Research is needed to study if the sensitivity to a persons environment such as light, touch, and sound can cause migraine progression. We hope to understand what makes migraine progress from not often to almost a daily problem. The information we gain may help us create better ways for people to prevent chronic migraine.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Migraines and Headaches

(IRB#: IRB_00156345)

Migraines and headaches are one of the most often pain people experience. Research is needed to better understand migraines and headaches. Including the pain, they may cause and quality of life. The information we gain may aid future patients.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Mirum VISTAS

(IRB#: IRB_00137626)

The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with PSC. Volixibat is an experimental treatment, meaning that it has not yet been approved by the US Food and Drug Administration or any worldwide regulatory body. Volixibat is a medicine that lowers circulating bile acid levels that are believed to lead to the itching in patients with PSC. There are no other medicines approved to treat itching in patients with PSC. This is the first time volixibat will be used in patients with PSC.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

MODEL Study: SB-01, A Study Drug for People with Degenerative Disc Disease in the Lower Back of the Spine

(IRB#: IRB_00154298)

Degenerative disc disease can occur in the lower back of a persons spine. This disease can cause severe back pain and cause disability. SB-01 is a study drug to help people with this disease. Research is needed to study the safety and effectiveness of this drug. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Motor Learning and Brain Development

(IRB#: IRB_00155118)

Motor learning is how a person functions using the brain. Young adult brain development is known as the best motor learning and memory behaviors. Some studies show a childs brain may be better at these. Research is needed to find if a childs brain is greater at motor learning and memory-related behaviors. The information we gain may aid future patients.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

MPS VII - Disease Monitoring Program

(IRB#: IRB_00137496)

This DMP will follow the disease in all enrolled individuals with MPS VII, regardless if they are receiving or not receiving Mepsevii. The DMP will observe how your disease changes over time by using several tests and questionnaires, which will be discussed later in this form. For those individualss who are receiving Mepsevii, this DMP will assess long-term effectiveness and safety of Mepsevii.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Multiple Sclerosis (MS), Autoimmune Diseases, and Infection

(IRB#: IRB_00047316)

The cause of Multiple sclerosis (MS) and autoimmune diseases is unknown. The effects of these can severely hurt a persons brain, spinal cord, and body. We want to understand how infections may relate to the diseases. The information we learn can aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

NERVE TRANSFERS TO IMPROVE UPPER EXTREMITY FUNCTION AND QUALITY OF LIFE IN TETRAPLEGIC PATIENTS

(IRB#: IRB_00126462)

The purpose of this study is to gather information about the treatment of Spinal Cord Injury (SCI) through the use of a surgical procedure known as a nerve transfer. SCI is a devastating condition which is thought to affect nearly 40 cases per million persons annually in the US. More than 50% SCI occur in the cervical spine (i.e., tetraplegia), resulting in some loss of arm and/or hand function. Nerve transfers are used to improve upper extremity and hand function in patients who have suffered from SCI. This is a treatment option that is available to all (appropriate) patients, and participation in this study is not necessary to receive this treatment. Participation in this study is voluntary, and is available only to those who meet certain eligibility criteria. These criteria will be reviewed on a case by case basis by the University of Utah Department of Neurosurgery's study team as potential participants express their interest in the study. Various appointments and/or diagnostic procedures may be scheduled in order to ensure the eligibility of potential patients. There is no financial cost to patients (aside from the standard costs of care) who participate in this study, and there are no direct financial benefits provided for doing so. Participants will be followed after the procedure both by the surgeon and the physical therapy team. This study does provide funding for the physical therapy services utilized in the long-term follow up phase, but this funding is limited. So participants are encouraged to schedule these visits appropriately. The information provided on this page is not exhaustive, so those who are interested in this study are encouraged to contact our study team to discuss any questions they might have. You can do this by contacting the study coordinator, Kirby Taylor, via telephone or email.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

New Magnetic Resonance Imaging (MRI) Software to Improve Diagnosis of People with Neurovascular Diseases.

(IRB#: IRB_00162281)

Magnetic Resonance Imaging (MRI) is a way to form pictures inside of a persons body. A new MRI software has been designed to improve the quality and diagnosis of neurovascular diseases in the brain and surrounding areas. These diseases can cause problems in the muscles and nerves of a persons body. We want to learn if new MRI software creates better pictures to help people with neurovascular diseases. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Novo Nordisk: NASH and semaglutide

(IRB#: IRB_00139687)

We are doing this study to see if the medicine called semaglutide can help patients with NASH get better and reduce their risk of future liver complications. NASH is a disease where fat, inflammation and scar tissue build up in the liver. Semaglutide may improve these liver damages. By improving liver damage it might be possible to prevent future liver complications. Semaglutide is already used by doctors to treat patients with type 2 diabetes in many countries. It is also used in research studies of patients with obesity and of patients with different stages of NASH.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Nutrition Education for Diabetes during Pregnancy

(IRB#: IRB_00167234)

This study is to better understand the thoughts and feelings of people who are pregnant with diabetes and have been in a nutrition education program. Diabetes during pregnancy known as gestational diabetes (GDM) is a common issue. We want to hear input and ideas for developing a new nutrition education program for people with this issue. People in this study will complete a brief survey and join a focus group to discuss their experiences along with a follow-up one on one conversation about nutrition. The focus group will be video, and audio recorded. The information will then be written word for word with no names identified. What we learn will help us better know how to develop a nutrition education program for people with GDM.

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  • Female Only
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Obinutuzumab: A Study Drug for Childhood-Onset Idiopathic Nephrotic Syndrome

(IRB#: IRB_00161524)

Idiopathic Nephrotic Syndrome is a type of kidney disease. This condition may require many hospital visits, new medications, and relapses. Obinutuzumab is a study drug to help improve the lives of children and young people with this issue and their families. Research is needed to learn how safe and effective Obinutuzumab is when compared to a currently used common drug. The information we gain may aid future patients.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Obinutuzumab: A Study Drug for People with Membranous Nephropathy

(IRB#: IRB_00148974)

Membranous Nephropathy (MN) is a rare kidney disease. Obinutuzumab is an approved drug for some cancers. It is a study drug to help people with MN. Research is needed to learn the safety and effectiveness of the study drug compared with the approved drug tacrolimus. The information we learn will aid future patients.

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  • All genders
  • Under 7 or over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Orvepitant: A study to Reduce Severe Coughing for People with Idiopathic Pulmonary Fibrosis (IPF)

(IRB#: IRB_00152984)

Idiopathic pulmonary fibrosis (IPF) is a condition that causes scarring of the lungs and severe coughing. Orvepitant is a study drug to reduce chronic coughing for people with IPF. Research is needed to learn the safety and effectiveness of the study drug. Our hope is to provide long-lasting control of chronic cough and a better quality-of-life. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Parent and Teenage Views of Smartphone Use During Free-time Use on Identity and Self-Concept

(IRB#: IRB_00161007)

Parents and teenagers have views about the impact smartphones have on teenagers. Research is needed to know how using smartphones during free-time impacts teenagers identity and self-concept. The information we learn may aid future parents in helping their children develop healthy smartphone use habits.

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  • All genders
  • Over 7 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Patient and Caregiver Perceptions of Family Wellbeing for Vascular Surgery

(IRB#: IRB_00166345)

Vascular surgery may be done to treat a wide range of people with heart and blood flow issues. Many patients with this procedure can be at risk for other health problems and are over the age of 65. The purpose of this study is to learn more about the needs of the family well-being of vascular surgery patients. This will help doctors better understand decision-making for the family's well-being. People in this study will complete a one-time interview and one-time questionnaires. The interview will be conducted over the phone. Participants will be given a total of $100 for completion of the interview and questionnaires at each time point before and after surgery

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Patients After a Stroke who Have Weakness in Either Arms or Legs

(IRB#: IRB_00169101)

Paresis can occur after a person has a stroke causing weakness in either the arms or legs. People who have paresis are at risk of having spasticity. This is when the muscles stiffen or tighten without control and can cause pain. The study wants to see what patients 12 months after the first stroke have spasticity. Participants in the study will complete surveys by phone or online (such as using a computer) and attend in-person study visits. If allowed, the study visits may happen at home. The amount of time spent in the study varies and can last up to 18 months after the first stroke. Participants will be paid for being in the study. Medical information will be collected to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Physical Inactivity and Muscle Health Recovery

(IRB#: IRB_00130232)

Times of physical inactivity such as illness, recovery from surgery, or injury in older adults and those who are overweight may harm muscle health. Research is needed to learn how different markers such as hormones and proteins in the blood and muscle respond to physical activity and recovery. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Platelet-Rich Plasma for Labrum Tears of the Hip

(IRB#: IRB_00173470)

Platelets are small cells found in the blood that help form clots and stop bleeding. Platelet-rich plasma is blood that contains more platelets than normal and can be given to help people with pain. Tears of the Labrum to the hip (the cartilage "suction cup" that holds the ball to the socket of the hip) cause hip pain. The study wants to see if a portion of the patient's blood, the platelets, will help relieve hip pain and function. Participation requires completing surveys by email, text message, in person, and/or by telephone. Medical tests will also be done to track the health of participants. Participants will receive a gift card for the time spent in the study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Preventing Firearm Suicide Deaths Among Black or African American Adults

(IRB#: IRB_00169397)

The purpose of this study is to learn from community members and health professionals about firearm safety and how health systems can better help to prevent firearm suicides in Black or African American communities. Interviews will be conducted with African American community members who own firearms to better understand how they feel about discussing firearm safety with health professionals. Interviews will also be conducted with health professionals to identify ways to improve Counseling on Access to Lethal Means (CALM) for Black or African American adults. Each interview lasts up to 60 minutes and may be conducted over Zoom or in person. All information is confidential.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Preventing Perinatal Depression using an Online Intervention in a Healthcare System

(IRB#: IRB_00159109)

Women may suffer from depression before and after childbirth. This is called perinatal depression. Access to mental health resources can be difficult in both urban and rural areas. An online prevention program as part of a healthcare system may be a tool to access education and mental health resources. Research is needed to learn if using this tool is effective at preventing perinatal depression. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Prevention for People with Type 2 Diabetes

(IRB#: IRB_00166946)

A persons lifestyle shows to help prevent diabetes. A persons health may be influenced by their partner. Research is needed to learn how useful and successful a diabetes prevention program is when educating a patient with type 2 diabetes and their partner. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Prevention for People with Type 2 Diabetes

(IRB#: IRB_00143079)

A persons lifestyle shows to help prevent diabetes. A persons health may be influenced by their partner. Research is needed to learn how useful and successful a diabetes prevention program is when educating a patient with type 2 diabetes and their partner. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Radiofrequency Ablation for People with Sacroiliac Joint Pain

(IRB#: IRB_00150067)

Radiofrequency ablation (RFA) is a way to help people with lower back pain. The pain is caused by swelling or arthritis in the sacroiliac joints. This is where the lower spine and pelvis connect in a persons back. Research is needed to compare 2 types of RFA electrodes (an object that allows electricity to enter and leave a persons body safely). We want to learn which electrode works best in reducing joint pain. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Ravulizumab: A Study Drug for Infants, Children, and Young Adults Ages 1 month to 18 years old with Thrombotic Microangiopathy (TMA) after Hematopoietic Stem Cell Transplant (HSCT

(IRB#: IRB_00135225)

Thrombotic Microangiopathy (TMA) is blood clots that form in the body from damaged cells. Hematopoietic stem cell transplant (HSCT) is when other cells are used from a persons body to create normal blood cells. Ravulizumab is a study drug to help infants, children, and young adults ages 1 month to 18 years old with this disease after having HSCT. Research is needed to learn if the drug is safe and effective. The information we gain may aid patients.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Realize Trial for Drug resistant focal onset seizures

(IRB#: IRB_00130130)

In this study, doctors want to find out if an investigational drug called CVL-865 is effective in decreasing the number of focal onset seizures, also known as partial seizures, without causing too many side effects.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Reflexes and Electrical Stimulation after Neurological Injury

(IRB#: IRB_00167330)

The purpose of this study is to learn how reflexes (a muscle reaction in the body) change in the lower back after neurological (the body's nervous system) injuries such as stroke, spinal cord injury, or leg amputation using non-invasive electrical stimulation (a small pad placed on the skin outside of the body that sends electricity to a muscle). We want to learn how and what a person feels from the stimulation and if it helps improve stability during standing and walking. We also want to learn if there are changes in pain, quality of life, and spasms (a sudden muscle movement in the body) after receiving this stimulation. People in this study will be placed into two groups based on their condition. Group 1 is people who have had a transtibial (below knee) amputation. Group 2 is people with chronic transtibial (below the knee) amputation pain, stroke, or spinal cord injury affecting at least one leg for at least 6 months before participation. Being in the study requires up to 9 weeks and 4 study visits. Each visit will last up to 6 hours depending on what needs to occur at the visit. Medical tests will be done during the study to track the health of participants. Participants will be paid $75 for participation.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Registry for Adenomas of the PItuitary and related Disorders (RAPID)

(IRB#: IRB_00144784)

This study is a surgical registry for patients who undergo surgical resection of pituitary adenomas. The registry allows surgeons and researchers to obtain more accurate data from patients because it is prospective, meaning it data is entered as the patient is treated. One problem with all prior studies is that patient charts are reviewed after treatment which can result in inaccurate data and bias. Clinical data such as visual function, endocrinology function, surgery time, and length of stay will be acquired in addition to other variables. Samples of removed tumor will be stored in the Huntsman Tumor Biobank. Patients will also be provided quality-of-life surveys, brief evaluations done at the time of clinic follow-up or by email, that allows surgeons to better understand how surgical treatment is helping their patients' life at home, ability to reenter the workplace, etc.The purpose of this study is to evaluate best practices, improve the accuracy of epidemiology information, and improve patient outcomes. This registry is part of a multicenter study where the top centers of excellence in the treatment of pituitary adenoma are collaborating to study their data together. Future plans for the registry are to expand to other types of skull base tumors to better understand patient treatment and improve outcomes.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

Relationship between Pupillary Function, Olfaction, Balance, and Cognition in People with Parkinsons Disease and Essential Tremor

(IRB#: IRB_00158420)

The purpose of the study is to use simple tools that could be used in a health clinic to identify people with Parkinson's disease and essential tremor. People with these health issues are at risk of falling or having dementia. We want to explore the relationship between the pupillary light reflex (the way the pupil constricts when exposed to light) and olfaction (smell) with balance and cognition in people with Parkinson's disease and essential tremor.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Rozanolixizumab: A Study Drug for People with Myelin Oligodendrocyte Glycoprotein (MOG) antibody associated disease (MOG-AD)

(IRB#: IRB_00148171)

Myelin Oligodendrocyte Glycoprotein (MOG) antibody-associated disease (MOG-AD) may inflame a persons central nervous system severely affecting nerves in the eyes, brain, and spinal cord. Rozanolixizumab is a study drug to help people with MOG-AD. Research is needed to learn the safety and effectiveness of the study drug. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Safety and Therapeutic Monitoring of Brain Stimulation in Patients with Partial Epilepsy

(IRB#: IRB_00146095)

The purpose of this research is to learn more about 10 daily sessions of transcranial direct current stimulation (tDCS) and see if it can help to reduce the frequency of seizures (the number of seizures in a given period of time) in both adults and children with refractory focal epilepsy (epilepsy that cannot be well controlled by seizure medication). The University of Utah anticipates enrolling five patients in this study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Shoulder RFA for the Treatment of Non-Surgical Shoulder Pain

(IRB#: IRB_00159158)

Shoulder pain can cause chronic health issues and costs. Currently, there are not many options to help people with this condition. Research is needed to learn the safety and effectiveness of shoulder radiofrequency ablation (SRFA) in patients with specific shoulder pain. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Skin Cancer Prevention Education for Pregnant Mothers and Their New Babies

(IRB#: IRB_00150970)

Skin cancer is the most commonly diagnosed cancer in the United States. Parents are important in their childrens sun safety. Research is needed to find out how possible and effective it is to provide sun protection education to pregnant mothers. While studying the effects of the mothers sun protection actions. The information we learn will aid future patients.

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  • Female Only
  • Under 7 or over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

SL-1002 Injection Treatment for People with Knee Pain and Osteoarthritis (OA)

(IRB#: IRB_00154817)

Osteoarthritis (OA) is a disease that causes joint pain. This can occur in the knee. The Corticosteroid dexamethasone injection is used now to help people with OA knee pain. The human amniotic fluid epidural injection is a new way to treat this pain. Research is needed to learn the safety and effectiveness of the new injection and see which injection is better at improving symptoms. The information we learn will aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Sleep and Cardiometabolic Disease

(IRB#: IRB_00164764)

Cardiometabolic disease may put a person at risk of diabetes and heart disease. The amount of time a person sleeps is one factor that can cause the risk of these health issues. Research is needed to learn specific ways to improve a person's nightly sleep that may lower disease risk. The research we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Social Safety on University of Utah Campus

(IRB#: IRB_00169088)

This study will help researchers understand how different campus settings feel to first-year students from different backgrounds and life paths. An app has been developed for students to use on a smartphone. The app will collect student experiences across different campus settings such as coffee shops, study areas, and classrooms. Students can choose to make lots or ratings, or only a few, and those who commit to making 15 different ratings will receive a $50 amazon gift card at the end of the study.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Sofosbuvir (SOF) and Velpatasvir (VEL): Study Drugs for Pregnant Women with Hepatitis C

(IRB#: IRB_00152415)

Hepatitis C is an infection in the liver. Sofosbuvir (SOF) and Velpatasvir (VEL) are approved drugs for people with Hepatitis C. These drugs are not approved for pregnant women with Hepatitis C. Research is needed to know the safety and effectiveness of these SOF and VEL for use in pregnant women. The information we learn may aid future patients.

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  • Female Only
  • Under 7 or over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Staccato Alprazolam: A Study Drug and Device for People with Stereotypical Prolonged Seizures

(IRB#: IRB_00154360)

Seizure emergencies can be long-lasting and hard to control with serious results. Typically, these seizures require drugs to help stop them from happening. Staccato Alprazolam is a new drug and tool combined to help stop this seizure. Research is needed to know the safety and effectiveness of this treatment. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Staccato Alprazolam: A Study Drug for People with Stereotypical Prolonged Seizures

(IRB#: IRB_00148186)

Seizures can be long-lasting and hard to control with serious results. Typically, these seizures require drugs to stop them from happening. Staccato Alprazolam is a new drug to stop this seizure. Research is needed to know the safety and effectiveness of this drug in people who have had prolonged seizures. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Stem Cell Transplants and Disease Prevention for Children with ALL, AML, or MDS

(IRB#: IRB_00153852)

Acute lymphocytic leukemia (ALL) is a type of blood and bone marrow cancer. Acute myeloid leukemia (AML) is a type of blood cell and bone marrow cancer caused by too many undeveloped white blood cells. Myelodysplastic Syndromes (MDS) are a rare group of bone marrow disorders, known as blood cancer. We want to learn if patients receiving stem cell transplants from donors of any type (related, unrelated, cord, or haploidentical) with specific characteristics (different genetic make-up known as polymorphisms) will have better results than those with different transplants. We want to see if fewer diseases such as Graft v Host Disease (GvHD) and other disorders occur. The information we gain may aid future patients.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Study Cuffless Blood Pressure

(IRB#: IRB_00162369)

This study is developing a new device to measure blood pressure (how the force of blood goes throughout the body). Normally people measure their blood pressure with an inflatable cuff on their arm. The new device is like a wristwatch with a sensor for blood pressure. People in this study will wear the new device while they exercise in a lab at the University of Utah. Other vital signs will be measured such as body temperature and weight and use an ultrasound machine (a way to see the inside of the body). These will help get more measurements to see if the new device works. The study session will last about 90 minutes.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Study in Parkinson Disease of Exercise

(IRB#: IRB_00136463)

This study seeks to determine if aerobic exercise influences the progression of Parkinson Disease severity. Based on previous research, we believe that aerobic exercise may protect the brain cells from being damaged and this study hopes to provide more specific evidence regarding this potential benefit.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Study of Eye Diseases That Lead to Visual Impairment

(IRB#: IRB_00010201)

There are certain eye diseases inherited and passed on from parents. Age-related macular degeneration and glaucoma are two of these diseases. Both can create vision loss or blindness. We are doing this research to find out more about the causes of these diseases and others. This will help us to know how best to test, treat, and maybe cure them. The information we learn in this study will aid future patients.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Study Ozanimod an Approved Drug for People with Crohns Disease

(IRB#: IRB_00115515)

Crohns disease (CD) can cause severe pain and swelling in a persons stomach. Ozanimod is an approved drug that can help people with this disease. We are doing this research to know more about how well ozanimod works. The information we learn in this study will aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Studying the genetic factors in smoking-induced vascular disease

(IRB#: IRB_00167355)

Our study will determine whether people who have genetic variants in nicotine receptors have a higher risk for smoking-induced vascular disease. Then we will study the mechanisms and identify potential therapy for smokers carrying genetic variants in nicotine receptors. Our study will educate people carrying genetic variants in nicotine receptors to stop smoking and will provide potential treatments against smoking-induced vascular disease for this population.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

SUBLIME - Study of Utahns' Beliefs and Life Experiences with Integrative Medicine

(IRB#: IRB_00164305)

This study is evaluating Utah's Medical Cannabis Program. The study will survey people with and without a medical cannabis card. Currently, participants are only enrolling people without a medical cannabis card. People in this study will receive electronic surveys that will ask about their health. Surveys are completed at three different time points over one year. Questions are asked about physical, behavioral, and medical health.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Paid

 

Suicidal Thoughts or Behavior During and After Pregnancy

(IRB#: IRB_00126952)

Pregnancy can be a stressful time in a womans life. This may cause women to have thoughts or actions about self-harm or suicide while they are pregnant. Research is needed to learn more about the effects of motherhood on mental health. The information we learn will help us provide better support for all women during and after pregnancy.

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  • Female Only
  • Under 7 or over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Teen Depression Therapy

(IRB#: IRB_00113733)

Depression is a mental health condition that can cause a loss of interest in activities and function in a persons daily life. This study wants to see if therapy can help teenagers stay healthy and prevent depression from happening again. Participants will receive therapy virtually on a computer or other device using Zoom or another method, complete surveys, computer testing, and a brain scan using an MRI (a tool to take pictures of the brain). Therapy sessions will be done weekly for 10-14 sessions. Participation lasts 2 years to assess depression. Participants will be paid for time spent in the study outside of therapy sessions.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Test to Determine Children with Idiopathic Membranous Nephropathy (IMN)

(IRB#: IRB_00152942)

Idiopathic Membranous Nephropathy (IMN) is a kidney disease. Research is needed to find out if blood tests predict when a child may have IMN. The information we learn will aid future patients.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

Testing a new drug called Trappsol® Cyclo in patients with Niemann-Pick Disease Type C1

(IRB#: IRB_00161309)

Niemann-Pick Disease Type C1 (NPC1) is a disease that may cause problems in the brain and the body. This study will test a drug called Trappsol® Cyclo in children and adults with NPC1 to see if it helps treat their disease. Participants in this study will be randomized to be treated with Trappsol® Cyclo or a placebo in an IV infusion. The IV infusion will happen in the clinic every 2 weeks. Being in this study requires up to 100 study visits at the clinic. Later in the study, participants on the placebo can be switched to Trappsol® Cyclo.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing a New Drug called Venglustat Compared to the Standard of Care on the Heart in Adults with Fabry Disease (The CARAT (EFC16158) Study)

(IRB#: IRB_00167895)

This study will test a new drug called Venglustat compared to the usual standard of care treatment in adults with Fabry Disease. This study is for people who have heart problems (enlargement of the heart's main pump (left ventricle)). Participants in this study will be randomized to be treated with Venglustat or one of the standard of care treatments. Later in the study, participants on the standard of care treatment can be switched to Venglustat. Participants will be in the study for 2 years and 2 months. There will be several clinic visits for the study and there may be the option for some home health visits. There will also be phone call visits.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing a new drug called Venglustat to treat nerve pain and abdominal pain in adults with Fabry Disease (The PERIDOT (EFC17045) Study)

(IRB#: IRB_00153570)

This study will test a new drug called Venglustat for treating nerve pain and abdominal pain in adults with Fabry Disease. This study is for people who have not been treated by enzyme replacement therapy or who stopped taking enzyme replacement therapy for at least 6 months. Participants in this study will be randomized to be treated with Venglustat or a placebo. Later in the study, participants on the placebo can be switched to Venglustat. Participants will be in the study for 2 years and 2 months. There will be several clinic visits for the study and there may be the option for some home health visits. There will also be phone call visits.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing a Person's Mobility

(IRB#: IRB_00171076)

This study wants to learn more about how people who either have no neurological (brain) injuries or who have had a stroke move around on different surfaces. These include stairs and uneven ground. The study wants to improve how a person moves with challenges such as a stroke survivor. People in the study will walk on different surfaces such as slopes, stairs, and uneven ground. While walking, information will be recorded from several sensors placed across the body (on the legs, in shoes, on wrist or around the chest). These sensors help collect how participants' muscles work, how they move, and how their heart rate changes as they walk on different surfaces. Being in the study requires attending at least one in-person session that will last up to 3.5 hours. People are paid for participation.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Testing a Study Drug Bexotegrast for People with Idiopathic Pulmonary Fibrosis

(IRB#: IRB_00171454)

Idiopathic Pulmonary Fibrosis is a disease that causes the lungs to scar and harden. This study will test a drug called Bexotegrast to treat people with this disease. The study wants to see if the drug will help people with the disease and is safe. People in the study will be randomly chosen to be treated with Bexotegrast 160 mg, or Bexotegrast 320 mg, or placebo. The placebo looks like the study drug but does not have the medication. Being in the study requires 8 in-person visits at the study clinic over about 58 weeks. Medical tests will be done to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing a Study Drug CMTX-101 Combined with Inhaled Tobramycin in People with Cystic Fibrosis Who Also Have Pseudomonas Aeruginosa

(IRB#: IRB_00171828)

This is a study to evaluate the new medication CMTX-101 in combination with inhaled Tobramycin in people with Cystic Fibrosis who also have Pseudomonas Aeruginosa. Cystic Fibrosis is a rare disease that mainly affects the lungs causing lung infections. Pseudomonas Aeruginosa is a type of bacteria (germ) that can cause infections in the body such as the lungs. Infections with Pseudomonas Aeruginosa are a leading cause of respiratory (breathing) failure and death in adults. The study will see if the drug will help people with the disease and is safe. People in the study will be treated with CMTX-101 in combination with inhaled Tobramycin. Being in the study requires about 35 days of participation. Including, 7 in-person visits at a study clinic and completing surveys. There are 2 parts of the study. People of part 1 will receive CMTX-101. People in part 2 will be randomly chosen to receive CMTX-101 or a placebo. The placebo looks like the drug but does not have the medication. People cannot be in both parts 1 and 2 of the study. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing a Study Drug Upadacitinib for Adults and Adolescents with Abbvie Hidradenitis Suppurativa

(IRB#: IRB_00168703)

Abbvie Hidradenitis Suppurativa is a chronic (continues over time) painful skin condition that occurs in the places where the skin folds on the body. This study will test Upadacitinib to treat adults and adolescents with this disease. The study wants to see if the drug will help people with the disease and is safe. People in the study will be randomly chosen to be treated with Upadacitinib or a placebo. The placebo looks like the drug but does not have the medication. The drug and placebo are taken as a swallowed pill. During the study some participants may switch from taking Upadacitinib or the placebo. Being in the study requires multiple ways of participation such as writing in a journal at home and attending in person at a study clinic for about 2 years. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing Dupilumab in Adults with Eosinophilic Gastritis with or without Eosinophilic Duodenitis

(IRB#: IRB_00171641)

Eosinophilic Gastritis with or without Eosinophilic Duodenitis is a rare disease of the stomach that can cause stomach pain and other health issues. This study will test a drug called Dupilumab to treat adults with this disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be randomly chosen to be treated with Dupilumab or a placebo. A placebo does not have the medication. The drug and placebo are taken as a liquid injection (a drug given under the skin). The study has 3 parts. Part A of the study people receive the drug or placebo. In part B of the study, people receive different doses of the study drug or the placebo. In part C of the study, all people will receive the study drug. Being in the study may require up to 20 study visits at the clinic for about 1.5 years. Medical tests will be done during the study to track the health of participants. People will be paid for being in the study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing Efzofitimod for Adults with Systemic Sclerosis Related Interstitial Lung Disease

(IRB#: IRB_00171090)

Systemic Sclerosis (hardening or tightening of the skin)-Related Interstitial Lung Disease is a rare disease that leads to severe health conditions. This study will test a drug called Efzofitimod to treat people with this disease. The study wants to see if the drug will help people with the disease and is safe. People in the study will be randomly chosen to be treated with Efzofitimod or a placebo. A placebo looks like the study drug but does not have the medication. The drug and placebo are taken as a liquid given under the skin. Being in the study will require 9 study visits at the clinic and last up to 32 weeks. Medical tests will be done during the study to track the health of participants. People will be paid for being in the study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing How to Improve Liver Organs for Transplantation

(IRB#: IRB_00158105)

This is a study to find new ways to improve liver organs for transplantation in people. Transplantation of liver organs requires using livers from people who are living or have died offering to donate their liver to help someone who needs a healthy liver. Participation in the study requires taking samples of the liver while having a liver transplant. If in a rare instance, a participant goes back right after surgery or for re-operation samples will be taken again. Participants health information and medical records will also be reviewed during the study. The information is confidential and will be kept in a secure database at 7 days, 1 month, 3 months, 6 months, 1 year, and 3 years after the transplantation.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Unpaid

 

Testing Inhaled Treprostinil in People with Idiopathic Pulmonary Fibrosis

(IRB#: IRB_00143600)

This study will test new a drug called Inhaled Treprostinil in people with Idiopathic Pulmonary Fibrosis (IPH). IPF is a disease that causes scarring in the lungs. The study wants to see if Inhaled Treprostinil will help people with IPF and is safe. People in this study will be randomly chosen to be treated with Inhaled Treprostinil or placebo. The placebo does not contain any medicine. Treprostinil and placebo are given by breathing the medicine into the lungs using a machine called a nebulizer (inhaling device). The nebulizer changes the medicine into a mist to breathe into the lungs. Being in this study requires about 8 clinic visits. Participation lasts about 58 weeks. Medical visits will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug Baricitinib in Patients Ages 6 to 18 Years Old with Alopecia Areata

(IRB#: IRB_00166438)

Alopecia Areata is sudden hair loss that often occurs in the hair on a persons head. This study will test a drug called Baricitinib to treat patients ages 6 to 18 years old with this disease. The drug has already been approved for adults with this condition. The study wants to see if the drug will help the specific age of patients with this disease. Participants will be treated with Baricitinib. The drug is taken as a liquid or a swallowed pill. Being in the study requires up to 18 study visits at the clinic over 2.5 years. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the drug Fluticasone Propionate in adults with eosinophilic esophagitis

(IRB#: IRB_00165383)

Eosinophilic esophagitis is a disease that affects the lining of the tube between your mouth and stomach. This study will test a drug called fluticasone propionate to treat adults with this disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be randomly chosen to be treated with fluticasone propionate or a placebo. The drug and placebo are taken as a swallowed pill. Later in the study, people on the placebo can be switched to the drug. Being in this study requires up to 15 study visits at the clinic over 48 weeks. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug HM15211 for People with Nonalcoholic Steatohepatitis

(IRB#: IRB_00136282)

Nonalcoholic Steatohepatitis (NASH) is swelling of the liver due to the buildup of fat in the liver cells of people who drink little or no alcohol. If swelling of the liver lasts it can lead to scarring (fibrosis) and serious medical issues. The study will test a drug called HM15211 to treat people with this condition. The study wants to see if the drug will help people with the condition and is safe. People in the study will be randomly assigned to one of four groups. Three of the groups will be treated with a different dose of the drug and one group will receive a placebo. The placebo looks like the study drug but does not have the medication. Being in the study requires up to 21 visits at the study clinic for about 65 weeks. People will write in a journal and complete other medical tests to track their health.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug INBRX-101 in Adults with AATD Emphysema

(IRB#: IRB_00169660)

AADT emphysema is a disorder where too much air collects deep in the lungs that is caused by the lack of a protein called alpha-1 antitrypsin (AAT) in the body. A deficiency of AAT (AATD) can damage the lungs and liver if not treated. The study will test a drug called INBRX-101 to treat adults with this disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be placed into two groups. Group 1 will receive INBRX-101. Group 2 will receive Zemaira. Being in the study requires attendance at the study center for up to 51 weeks once a week to receive treatment with either INBRX-101 or Zemaira. Other study visits will be required for medical tests to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug Lorundrostat in Adults with Uncontrolled Hypertension

(IRB#: IRB_00165346)

Uncontrolled Hypertension is when the blood flow in the body is too high against the arteries and is unable to be controlled. This study will test a drug called Lorundrostat or MLS-101 to treat adults with this condition. The study wants to see if the drug will help people with the health condition. People in this study will be randomly chosen to be treated into three different groups. One group will receive the same daily amount of Lorundrostat or MLS-10. Another group will receive the same daily amount and then increase the daily amount. While a different group receives a placebo. A placebo does not have the treatment. The drug and placebo are taken as a swallowed pill. Being in the study lasts up to 5 months with a total of 9 clinic visits. Participants will be paid $50.00 per visit. Medical tests are done to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug Ozanimod in adults with Ulcerative Colitis (UC)

(IRB#: IRB_00164781)

Ulcerative colitis (UC) is a disease that inflames a persons digestive system (how food is processed in the body) causing health problems such as stomach pain, fever, and even an increased risk of colon cancer. This study will test a drug called ozanimod to treat adults with this disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be placed into two groups based on their medication use. Group 1 will be people who have used standard UC medication. Group 2 will be people who have used advanced UC medication. Being in the study requires 2.4 years and about 8 visits to the study center. Each visit may vary from 2-7 hours depending on what needs to occur at each visit. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug PTC923 (Sepiapterin) in People with Phenylketonuria

(IRB#: IRB_00150586)

Phenylketonuria (also called PKU) is a condition in which your body can't break down an amino acid called phenylalanine. This study will test a drug called PTC923 (Sepiapterin) to treat people with Phenylketonuria. The study wants to understand the long-term safety in patients with PKU and changes in diet. People in this study will be placed into two groups depending on their blood phe levels to be treated with PTC923 (Sepiapterin). The drug is taken as a swallowed pill. Being in the study may require about 15 visits at the study clinic and some may be virtual visits on the phone. This is determined by participants' assigned groups. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug Tolvaptan for Infants and Children with Autosomal Recessive Polycystic Kidney Disease

(IRB#: IRB_00161351)

Autosomal Recessive Polycystic Kidney Disease is a rare kidney disease that causes poor kidney function in infants and children. This study will test a drug called Tolvaptan to treat infants and children with this disease. The study wants to see if the drug helps infants and children with this disease and is safe. Infants and children in the study will participate in at least 11 in-person study visits at the clinic and 9 more visits have the option of home health visits. Participation lasts about 19 months. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug Ubrogepant in Adults and Young Adults with Migraine

(IRB#: IRB_00149183)

Migraine is a reoccurring headache that varies in pain and can cause other health issues such as sick to the stomach, and sensitivity to light and sound. The study will test a drug called Ubrogepant to treat people with the disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be randomly treated with the Ubrogepant or a placebo. The drug and placebo are swallowed as a pill. This placebo does not have the treatment. Participation in the study is about 6-7 months. Medical tests will be done in-person, on the phone, and online such as using a computer during the study to track the health of participants.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Drug VE202 in Adults with Mild-to-Moderate Ulcerative Colitis

(IRB#: IRB_00168499)

Mild-to-Moderate Ulcerative Colitis (UC) causes inflammation of the large intestine (colon). This study will test a drug called VE202 to treat adults with this disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be randomly chosen to be treated with the study drug VE202 or a placebo. The drug and placebo are taken as a swallowed pill. The placebo does not have the treatment. Later in the study, people on the placebo are switched to the drug, and people on the drug are switched to the placebo. Participation in the study requires up to 2.5 years. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the drug XEN1101 in adults with epilepsy

(IRB#: IRB_00164793)

This study will test a new study drug called XEN1101 to help patients with epilepsy. Epilepsy is a disease that may occur due to a genetic disorder or brain injury. This condition affects the nerves in the brain causing seizures. The study wants to see if XEN110 will help people with the disease and is safe. People in this study will all receive XEN1101 once a day. The drug is taken as a swallowed pill. Being in the study requires regular clinic visits for about 8 months during participation. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Study Drug Barzolvolimab (CDX-0159) in Adults with Active Eosinophilic Esophagitis

(IRB#: IRB_00170529)

Eosinophilic esophagitis is a disease that affects the lining of the tube between your mouth and stomach. This study will test a drug called Barzolvolimab (CDX-0159) in adults with this disease. The study wants to see if the drug will help people with the disease and is safe. People in this study will be randomly chosen to be treated with doses of Barzolvolimab (CDX-0159) and placebo. The drug and placebo are taken as a swallowed pill. A placebo is a pill that does not have the drug. Being in the study requires up to 50 weeks at the clinic. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Study Drug BLU-5937 for Adults with Refractory Chronic Cough (RRC) Including Unexplained Cough

(IRB#: IRB_00160784)

Refractory Chronic Cough (RCC) is a cough lasting more than 8 weeks that has not improved after treatment for possible causes (such as acid reflux, asthma, or nasal congestion). An unexplained cough is a cough lasting more than 8 weeks that does not have a known cause, even after a thorough medical evaluation and testing. This study will test a drug called BLU-5937 in adults with these conditions. The study wants to see if the drug will help people with RCC or unexplained cough and is safe. People in this study will be randomly chosen to be treated with doses of BLU-5937 and placebo. The drug and placebo are taken as a swallowed pill. A placebo is a pill that does not have the study drug. Participation in the study will last up to 1.5 years. The study will consist of a 4-week screening period, a 79-week study drug treatment period, and a 2-week follow-up period. Participants will be asked to attend up to 19 visits at the study center to complete the study assessments and procedures. Participants will also have 6 phone calls from the study team, to check on participants health. Study procedures include a chest x-ray or CT scan, physical exams, blood tests, breathing tests, questionnaires, wearing a cough monitor, and taking the study drug. Participants will be compensated at time points throughout the study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Study Drug Crovalimab in People with Atypical Hemolytic Uremic Syndrome

(IRB#: IRB_00161592)

This study will test a new treatment called Crovalimab to treat people with Atypical Hemolytic Uremic Syndrome (aHUS). aHUS is a rare disease that causes tiny blood clots to form in the small blood vessels of the body. This condition can lead to organ damage and failure in the body such as kidneys. The study wants to see if Crovalimab will help people with this disease and is safe. People in this study will be placed in one of three groups; people who have not been treated with Crovalimab, people who are changing their current treatment from Eculizumab or Ravulizumab to Crovalimab, or people who received Eculizumab or Ravulizumab in the past, the treatment stopped, and now a doctor decided to restart the treatment. The amount of Crovalimab a person receives depends upon the weight of the participant. Crovalimab is given as a liquid into the participants vein and given under the skin. Study participation may be up to 7 years and requires attending in-person at study clinics. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

Testing the Study Drug Oral Paricalcitol in Infants and Children with Chronic Kidney Disease Peritoneal Dialysis of Hemodialysis

(IRB#: IRB_00141843)

Chronic Kidney Disease Peritoneal Dialysis of Hemodialysis is a disease that can lead to kidney failure and is treated by giving fluid into the body to clean the blood. This study will test a drug called Oral Paricalcitol to treat infants and children ages 0 to 9 years old with stage 5 (patients with an average of 5 to 10 years left of life). The study drug has been approved for patients ages 10 to 16 years old. The study wants to see if the drug will help infants and children ages 0 to 9 years old with this disease and is safe. Patients in the study will be treated with Oral Paricalcitol. The drug is taken as a swallowed liquid. There are 3 ways to participate in the study. These include in-person study visits at the clinic, at home with a nurse, or over Zoom (a virtual way to attend a visit on a technology device such as a computer) with help from a nurse. Participation is about 43 weeks. Medical tests will be done to track the health of participants.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Study Drug TN-201 in Adults with Symptomatic MYBPC3 Mutation-Associated Hypertrophic Cardiomyopathy

(IRB#: IRB_00166206)

Symptomatic MYBPC3 (a gene found in the muscle of the heart) mutation-associated non-obstructive hypertrophic cardiomyopathy is one of the most common inherited cardiac (heart) diseases. This study will test a drug called TN-201 to treat adults with this disease. The study wants to see if the drug will help people with this disease and is safe. The study will have 2 groups of people receiving different doses of the study drug. All participants will receive the study drug. The drug is given as an infusion (liquid drug given under the skin). Being in the study requires meeting in person at a study clinic at different periods of time over 5 years. Participants will receive payment for participation. Medical tests will be done to track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Study Drug Tolvaptan for Children with Autosomal Recessive Polycystic Kidney Disease

(IRB#: IRB_00150059)

Autosomal Recessive Polycystic Kidney Disease is a rare kidney disease that causes poor kidney function in children. This study will test a drug called Tolvaptan to treat children with this disease. The study wants to see if the drug helps children with this disease and is safe. Children in the study will participate in at least 11 in-person study visits at the clinic and 14 more visits have the option of home health visits. Participation lasts about 25 months. Medical tests will be done during the study to track the health of participants.

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  • All genders
  • Under 7 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Testing the Timing of Tics Over Time in Children with Persistent Tic Disorders, Including Tourette Syndrome

(IRB#: IRB_00171031)

This is a study is to learn the timing of tics over time in children with Persistent tic disorders, including Tourette syndrome. These conditions are brain disorders that cause uncontrolled body movements and sounds. This behavior may improve and worsen depending on what happens to a person throughout a lifetime. Being in the study requires a child and their parent to attend 6 private video visits using a computer with internet. Visits will include interviews, surveys, learning activities, and training. Participation in the study lasts about 7 hours. All visits will be video recorded and kept in a secure place.

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  • All genders
  • Over 7 years old
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

Testing the Treatment of Donor Cell Transplants for Children and Young Adults with Severe Myeloid Leukemia

(IRB#: IRB_00152764)

This study is testing the treatment with Natural Killer cells from a donor to a patient, which may lower the chance that a blood disease severe myeloid leukemia will come back after a haploidentical (half-matched) transplant (moving cells from a donor to a patient). The study wants to see if the treatment will help people with severe myeloid leukemia. People in the study will receive Natural Killer cells from a central line placed in the body, most likely the chest. A central line is a tube that allows medications, medical tests, and transfusions to occur. Transfusion is a way to move blood from a donor to a patient. Being in the study requires attending in-person study visits at a clinic for about 2 years. Medical tests will be done to track the health of participants.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Tezepelumab: A Study Drug for Patients with Eosinophilic Esophagitis (EoE)

(IRB#: IRB_00162145)

Eosinophilic Esophagitis (EoE) is a disease that may cause vomiting and heartburn and make swallowing difficult. Tezepelumab is a study drug for patients with EoE. Research is needed to learn if Tezepelumab is safe and effective at helping people with EoE. We also hope to better understand EoE and health problems related to the disease. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

The Attention of Expert Boxers

(IRB#: IRB_00155440)

Making instant decisions is important in a variety of settings, including sports such as boxing. When time is limited, decision-making success is strongly determined by things that influence immediate attention. Research is needed to learn whether expert boxers show better attention skills compared to untrained persons. The information we learn may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

The Intracept Procedure for People with Low Back Pain

(IRB#: IRB_00130205)

The Intracept procedure is given by a patients specific doctor for low back pain. The procedure is approved by the (Food and Drug Administration) FDA. Research is needed to learn more about how well and safe it is at helping a persons lower back pain. The information we learn will aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

The SPRINT® System a Nerve Stimulator for People with Head Pain

(IRB#: IRB_00159617)

The SPRINT® system can block nerves that send pain signals to the brain. Research is needed to learn how safe the SPRINT® system stimulator is and how well it helps people with head pain. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Thought Processes when Forming Words

(IRB#: IRB_00171949)

This study wants to learn how a person's thoughts form words. People in the study will view pictures on a computer and be asked to describe what they see. The responses will be recorded. Being in the study requires attending in person at the University of Utah. Participants will be paid for being in the study.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Thoughts of Expanded Carrier Screening (ECS)

(IRB#: IRB_00163720)

Expanded carrier screening (ECS) is a type of genetic screening offered to people of childbearing age with information about recessive genetic conditions (2 nonworking copies of a gene that can cause a disorder). This issue does not affect the health of parents but may be passed on to affect the health of their baby. We want to learn the thoughts and feelings of women who are or may become pregnant about ECS. The information we gain may aid future patients.

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  • Female Only
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Timing of Exercise on Diabetes and Sleep

(IRB#: IRB_00156659)

Older adults who have overweight or obesity, low physical activity, and poor sleep may be at a higher risk for developing diabetes. Research is needed to learn if exercise in the morning or afternoon/evening is better at reducing the risk of diabetes and improving sleep. The information we gain may aid in the prevention and treatment of diabetes for future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Tobacco and Alcohol Use Among People with Low Income

(IRB#: IRB_00170612)

The study wants to learn the reason people engage in certain behaviors. The study team wants to know how certain factors such as emotions, and social and psychological factors on discrimination impact the use of tobacco and alcohol among people who are low income. Being in the study will last about 9 years requiring 2 visits from the participants home. One online virtual visit at the beginning of the study and one phone call at the end of the study. Participation also requires downloading an application on the participants cellphone and answering up to 8 short phone surveys on the smartphone per day for 7 days in a row. The surveys will ask the participant about feelings, experiences, emotions, smoking, and drinking behaviors.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   From Home
  • Paid

 

Tocilizumab or TCQ: A Study Drug for Pediatric Patients with COVID-19

(IRB#: IRB_00150759)

Tocilizumab or TCQ is a study drug to help pediatric patients hospitalized with COVID-19. Research is needed to learn if it is safe and effective for these patients. The information we gain may aid futures patients.

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  • All genders
  • All Ages
  • Volunteers with special conditions
  •   In Person
  • Paid

 

TRADIPITANT: A Study Drug to Help People with Gastroparesis

(IRB#: IRB_00129133)

Tradipitant is a study drug to help people with symptoms of gastroparesis, a stomach disease. Research is needed for us to know the effects of the study drug. The information we learn will help us understand if it can improve the health of people with gastroparesis.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Transcranial Magnetic Stimulation (TMS) for People with Depression in Multiple Sclerosis (MS)

(IRB#: IRB_00164631)

Multiple sclerosis (MS) is a disease that damages nerve cells in the brain and spinal cord. This can affect a persons physical and mental health. Depression, or major depressive disorder, is common in people with MS and often has a serious impact on quality of life. Depression can be difficult to treat with medications in MS. Transcranial magnetic stimulation (TMS) is a safe and approved treatment for medication in people with depression. Little is known about TMS for people with MS. This study wants to better understand the safety and effectiveness of TMS treatment for depression in MS. Participants will receive standard outpatient TMS treatment for depression. This includes in-person, phone, and online Zoom visits to complete surveys and track the health of participants.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Treating healthcare provider burnout using Psilocybin-Assisted Psychotherapy and Mindfulness-Based Stress Reduction

(IRB#: IRB_00152312)

Many healthcare providers on the frontlines of the SARS-CoV-2 pandemic felt burnt out and depressed. We want to see if mindfulness training helps with these feelings. We also want to see if psilocybin-assisted therapy helps with these feelings. The frontline healthcare providers who sign up will get mindfulness training for 8 weeks. Half of the providers will also get psilocybin-assisted therapy.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Treating Obstructive Sleep Apnea with the Aura6000® System

(IRB#: IRB_00150772)

The aura6000® system is a device that helps open the airway while a person sleeps to prevent obstructive sleep apnea (OSA). Research is needed to see if it is safe and effective to reduce OSA. This information will help determine if this device may be used to improve the care and quality of life for people with OSA.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Understanding how to prevent regaining weight after weight loss for adults who are overweight

(IRB#: IRB_00166611)

We are doing interviews with generally healthy adults who are overweight now or have been in the past. The interviews will be 30 minutes long and ask many questions. Some of the questions will be about things that may cause a person to regain weight they had lost, and how to get additional help from a professional to support weight loss. The interview can be done in-person or on Zoom. People in this study will also need to have their height and weight measured at the University of Utah.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

University of Utah Long Covid Registry

(IRB#: IRB_00140978)

Researchers at the University of Utah have established a registry to follow individuals who are experiencing prolonged symptoms after COVID-19 infection. We are interested in following people with "Long Covid" using in depth health surveys and optional blood draws to better understand this condition with the goal of ultimately developing clinical management strategies.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   From Home
  • Unpaid

 

Utah Childrens Project: A Study Before, During, and after Pregnancy

(IRB#: IRB_00063183)

Environment and genetics can impact the health of families for generations. We want to learn more about how exposures to the environment affect the health and development of children before, during, and after pregnancy. Research is needed to understand how various physical, chemical, biological, social, behavioral, and natural environments may relate to childhood diseases. The information we gain may lead to better health for future generations.

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  • All genders
  • All Ages
  • Healthy Volunteers
  •   In Person
  • Paid

 

Vanpools for Frontline Healthcare Workers

(IRB#: IRB_00166630)

Sick of the stress of commuting? Done with traffic? Then join the Vanpool Trial at the U! We are looking for participants who want to change how they commute to UHealth. Anyone who commutes to a UHealth location is eligible to participate. We are testing Vanpools, in partnership with UTA and UCAIR, to understand how it impacts employee commute stress, quality of life, and your views of public transit and climate change. Vanpools are shared commute vans that a group of people use to get to and from a neighborhood to work. Eligible participants will be randomized to either a vanpool or a educational intervention, so you must be willing to join a vanpool for up to 5 months. Contact us today to learn how you can join!

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Unpaid

 

Viewing Events

(IRB#: IRB_00170628)

The purpose of this study is to determine what people remember from experiences they have in Virtual Reality. We will ask you demographic questions and about your experience with VR. You will view a fictional park scenario presented through a virtual reality (VR) headset, and we will measure where you look and your physiological responses (e.g., heart rate, perspiration) using non-invasive wearable technology. Then we will ask you about the video. Participation in the study requires one study visit and should last up to an hour. Participants will be compensated for their time.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Virtual Reality and Mindfulness Therapy for People with Opioid Use Disorder

(IRB#: IRB_00157860)

Virtual reality is a technology device used to create an unreal environment for people to face situations such as Opioid (drug) Use Disorder (OUD). A therapy called Mindfulness-Oriented Recovery Enhancement (MORE) has been shown to help people with chronic pain and other issues of OUD. Research is needed to learn if VR with MORE is just as well as MORE without VR. We hope to apply what we learn to better help people using Telehealth (doctor visits received outside of doctors offices such as on a computer). The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Voice Exercise Program

(IRB#: IRB_00162035)

A vocal cord produces a persons voice. Research is needed to better know how a vocal cord works. We want to see if a voice exercise program improves a person's pitch range. This is how high or low a persons voice can sound. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

Volixibat: A Possible Rare Liver Disease Medication

(IRB#: IRB_00148152)

PBC is a chronic rare liver disease. Volixibat is a potential medication for symptoms of this disease. Scientists and doctors do not know the safety and effectiveness of this drug. Research is needed to learn if it may be approved by the United States Food and Drug Administration (FDA) and then used to improve the health of PBC patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

VRDN-001: A Study Drug for People with Thyroid Eye Disease

(IRB#: IRB_00152628)

VRDN-001 is a study drug for people with thyroid eye disease. Research is needed to learn the safety and effectiveness of the study drug. The information we gain may aid future patients

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

VX-864: A Study Drug for People with Alpha-1 Antitrypsin Deficiency who have the PiZZ Genotype

(IRB#: IRB_00163260)

Alpha-1 Antitrypsin (ATT) Deficiency with the PiZZ Genotype is a genetic disorder that may result in severe health issues such as lung or liver disease. VX-864 is a study drug to improve the health of people with this condition. Research is needed to learn the safety and effectiveness of VX-864. The information we gain may aid future patients.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Working In-Person or Online for Team Problem Solving

(IRB#: IRB_00163653)

In the past, research has shown that working in person for team problem-solving provides better results. Currently, people are working more online. Research is needed to learn if working online for team problem-solving can also produce successful results.

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  • All genders
  • Over 18 years old
  • Healthy Volunteers
  •   In Person
  • Paid

 

XEN1101 Drug Study for People with Primary Generalized Tonic-Clonic Seizures

(IRB#: IRB_00159508)

The purpose of this research is to learn more about the drug XEN1101 and see if it can help to reduce the frequency of seizures (the number of seizures in a given period of time) in adults with primary generalized tonic-clonic seizures. The University of Utah anticipates enrolling five patients in this study.

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

XEN1101: A Drug Study for People with Focal-Onset Seizures

(IRB#: IRB_00159379)

The purpose of this research is to learn more about the drug XEN1101 and see if it can help to reduce the frequency of seizures (the number of seizures in a given period of time) in adults with refractory focal epilepsy (epilepsy that cannot be well controlled by seizure medication).

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  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

ZYN002: A Study for Children and Adolescents with Fragile X Syndrome (FXS)

(IRB#: IRB_00146490)

Fragile X Syndrome (FXS) is when a gene in a persons body stops making protein. This protein is needed for a persons brain development. ZYN002 is a gel put on the skin to help children and adolescents with FXS. Research is needed to learn more about the efficacy and safety of ZYN002. The information we gain may aid future patients.

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  • All genders
  • Under 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

 

Last Updated: 6/8/23