How does brain function change during a treatment cycle of Botox injections for the voice disorder adductor laryngeal dystonia?
The purpose of this study is to find the locations in the brain that are affected by Botox injections into the throat muscles in patients who have adductor-type laryngeal dystonia (also known as adductor spasmodic dysphonia). Participation in this study involves brain scans along with assessments of the voice muscles. Brain scans involve 1) laying still in a scanner while resting and speaking and 2) wearing a head cap while seated and reclined during speaking tasks. Assessment of voice muscles involves small needles inserted into muscles in the voice box. All procedures are well-tolerated by most people. Participants with laryngeal dystonia will have 4 brain scans (2 of each kind) and 2 voice muscle assessments over 1 Botox cycle (approximately 3-4 months). A second purpose of this study is to evaluate a specialized speech therapy program for treating laryngeal dystonia. Therapy will take place over 6 months (2 Botox cycles) and will incorporate in-person or virtual session along with home practice. Some participants may be eligible to participate by completing only some portions of the study.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
Who can participate?
Gender: All genders
Age: Over 18 years old
Volunteers: Volunteers with special conditions
Location: In Person
- 18+ years of age
- Normal hearing or mild-moderate hearing loss
- Consistent dose and response to Botox for at least 3 consecutive Botox injections (including the current injection)
- Metal in the body that is not MRI compatible (for fMRI only)
- Aversion to needles affecting your ability to participate in the study (for muscle assessment only)
- Currently pregnant
- Any other neurological disorder (other than adductor-type laryngeal dystonia in the patient group)
- Psychological disorders besides depression and anxiety
Will I be paid for my time?