Study Details
(SFCA) Microbial Metabolite Supplements on Eosinophilic Esophagitis Microbiome
(IRB#: IRB_00185556)
The purpose of the study is to understand the impact of microbial metabolite supplements called short chain fatty acids (SCFA) on the microbiome and immune signatures in eosinophilic esophagitis. People in the study will have an endoscopies, complete surveys, and other medical tests. Participants with active EoE will receive the study treatment twice daily for 8 weeks. Follow up medical tests will be done during the study to track the health of participants. Participants will be paid for study completion.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Who can participate?
Gender: All genders
Age: Over 18 years old
Volunteers: Volunteers with special conditions
Location: In Person
Inclusion Criteria
- Ages 18-90
- Diagnosis of Eosinophilic Esophagitis
- Having an upper endoscopy to test if proton pump inhibitor treats the disease
- Do not respond to proton pump inhibition and must continue the proton pump inhibitor throughout the entire study
- Willing to avoid other EoE treatments such as diet elimination or steroids
Exclusion Criteria
- Patients with recent antibiotic exposure (3 months), probiotic use (2 weeks) are excluded; and subjects must avoid other EoE treatments such as diet elimination or steroids (3 months; esophageal or systemic) to minimize confounding.
- Pregnant or Breastfeeding Patients
- Patients will also be excluded if they have known allergies to formulation components (e.g., sodium propionate, sodium butyrate, and honey), Esophageal complications that may impair safe administration (e.g., history of perforation, strictures requiring recent dilation, severe dysphagia, aspiration risk), Other significant comorbidities that may increase risk, or conditions other than EoE which are associated with esophageal eosinophilia (e.g., parasitic infections, drug hypersensitivity, hypereosinophilic syndrome, inflammatory bowel disease).
Will I be paid for my time?
Yes
IRB#: IRB_00185556
PI: Amiko Uchida
Department: GASTROENTEROLOGY
Approval Date: 2025-04-23 06:00:00
Specialties: Gastroenterology
I am Interested