Study Details
Testing the Drug REGN7544 for People with Postural Orthostatic Tachycardia Syndrome
(IRB#: IRB_00184156)
Postural Orthostatic Tachycardia Syndrome (POTS) is a condition that causes a serious increase of heart rate when standing up from sitting or lying down. This study will test a drug called REGN7544 to treat people with POTS. The study wants to see if the drug will help people with the condition and is safe. People in the study will be randomly chosen to be treated with the study drug REGN7544 or a placebo. The drug and placebo look the same, but the placebo does not have the medication. People in the study will wear a cardiac (heart) monitor on the chest. Being in the study requires up to 8 visits at the study clinic over about 18 weeks. Medical tests will be done during the study to track the health of participants.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Who can participate?
Gender: All genders
Age: Over 18 years old
Volunteers: Volunteers with special conditions
Location: In Person
Inclusion Criteria
- Ages 18 to 55 years old
- Diagnosed with POTS with specific criteria
- Ongoing symptoms of POTS such as lightheadness, weakness, blurred vision, and being tired that are worse with standing and relieved when lying done for at least 3 months before participation
- Specific body weight
- Able to attend in person at the study clinic
Exclusion Criteria
- History of hypertension (high blood pressure) or seated blood pressure with specific measures
- Seated blood pressure during active stand test with specific measures
- Increase in heart rate less than 20 beats per minute within 10 minutes of changing from supine position (laying down on the back face up) to standing position
- Significant heart failure, heart disease, or renal (kidney) disease that impacts study participation
- Confined to bed more than 50% of the day
Will I be paid for my time?
Yes
IRB#: IRB_00184156
PI: Guillaume Lamotte
Department: UNIVERSITY OF UTAH
Approval Date: 2025-03-26 06:00:00
Study Categories: Brain Health Studies
Specialties: Neurology
I am Interested