Study Details
Testing Treatments for People with Amyotrophic Lateral Sclerosis
(IRB#: IRB_00143448)
Amyotrophic lateral sclerosis (ALS) is a serious disease that affects the nerves in the brain and spinal cord. It causes muscles to weaken over time and can lead to death. This study is testing a drug called fluticasone propionate in adults with ALS. It will also look at four treatmentsZilucoplan, Verdiperstat, CNM-Au8, and Pridopidineto see if they are safe and if they help people with ALS. Participants in the study will be randomly assigned (like flipping a coin) to receive one of the treatments or a placebo (a substance with no active drug). The study lasts about 10 months and includes up to 8 clinic visits and 5 phone visits. During the study, medical tests will be done to check participants health.
- All genders
- Over 18 years old
- Volunteers with special conditions
- In Person
- Paid
Who can participate?
Gender: All genders
Age: Over 18 years old
Volunteers: Volunteers with special conditions
Location: In Person
Inclusion Criteria
- 18 years and older
- Sporadic or familial ALS diagnosed as clinically possible
- ASL for at least 36 months before participation
- Must either not take Riluzole or be on a stable dose of Riluzole at least 30 days before participation
- Must either not take Edaravone or have completed at least one cycle of Edaravone at least 30 days before participation
Exclusion Criteria
- Unstable medical condition other than ALS
- Unstable mental health condition
- Active or history of specific cancers
- Use of other treatments for ALS
- Pregnant or breastfeeding
Will I be paid for my time?
Yes
IRB#: IRB_00143448
PI: Summer Gibson
Department: NEUROLOGY
Approval Date: 2021-09-28 06:00:00
Study Categories: Brain Health Studies
Specialties: Neurology
I am Interested