Study Details
Testing the Drug JNT-517 in People with Phenylketonuria
(IRB#: IRB_00185433)
Phenylketonuria (PKU) is a condition in which a persons body does not break down an amino acid called phenylalanine. People with PKU must follow a special diet limiting the amount of protein they eat. This study will test a drug called JNT-517 to treat people with this disease. The study wants to see if the drug will help people with the disease and is safe. People in the study will be randomly chosen to be treated with JNT-517 or a placebo. A placebo looks like the study drug but does not have the medicine. The drug and placebo are taken as a swallowed pill. Being in the study requires attending in person visits at the study clinic with an option for a couple home visits over about 9 to 13 weeks. Participants will keep a diet diary. Medical tests will be done during the study to track the health of participants.
- All genders
- 7 to 17 years old
- Volunteers with special conditions
- In Person
- Paid
Who can participate?
Gender: All genders
Age: 7 to 17 years old
Volunteers: Volunteers with special conditions
Location: In Person
Inclusion Criteria
- Ages 12 to 18 years old
- Diagnosed with Phenylketonuria
- Able to swallow pills
- Must use birth control during and at least 30 days after study participation
- Able to attend in person visits at the study clinic
Exclusion Criteria
- Pregnancy
- Liver disease
- History of drug or alcohol abuse in the last year
- Surgery or medical condition that affects the study drug
- Participation in another drug trial within 30 days before participation
Will I be paid for my time?
Yes
IRB#: IRB_00185433
PI: Ashley Andrews
Department: PEDIATRIC ADMINISTRATION
Approval Date: 2025-04-17 06:00:00
Specialties: Pediatric Genetics
I am Interested