Search Criteria: Bone and Muscle Studies;
Lumbar Radiofrequency Ablation for People with Low Back Pain
Lumbar radiofrequency ablation (LRFA) is a treatment used to prevent a targeted nerve in the body from sending pain signals to the brain. This study will compare treatments for low back pain. Participants with chronic low back pain will be randomly assigned to a lumbar radiofrequency ablation (LRFA) or another treatment that may improve pain. The study wants to learn how well LRFA works to improve low back pain. Study participation will take about 3 to 4 hours over 12 months. (IRB#: IRB_00181348)
A Medtronic Product Follow-up Registry
This study will collect information into a follow-up registry from people who have used or intend to use a Medtronic Product. The information collected will be to continue Medtronic product safety and effectiveness and understand the range of product usage in clinical environments such as hospitals. This will help guide development and improvement of medical devices and therapies for patients that inform clinical research. People in the study will provide health information. This includes medical records, interviews, phone calls, mail, emails from the participant, family members, and/or doctors or other health providers. Participants will attend all regularly scheduled doctor visits, tell doctors about medical history, and report any health events such as injuries or hospitalizations. There is no registry end date. (IRB#: IRB_00184960)
Barriers to Low Back Pain Healthcare for People who are Underserved
Low back pain can require imaging (taking a picture) and other medical needs of the lumbar, (lower part of the back). People may have issues attending appointments for their lower back pain. These include language and translation services and lack of health insurance. The study wants to learn how to better help people attend their appointments for low back pain. Being in the study requires completing a survey. The questions may ask about needing an interpreter, health insurance, childcare, or transportation. People who need health insurance or an interpreter will be given help to attend the appointment. The study team will gather data to learn how to better help participants attend doctor appointments. Information collected will not identify the persons name, address, or phone number. (IRB#: IRB_00156672)
Cervical Medial Branch Radiofrequency Ablation (CMBRFA) compared to Trident Multi-tined Cannula for People with Cervical Facet Pain
Cervical facet pain is an arthritis-like joint pain that can be chronic and occur in the back and neck of the spine. Cervical medial branch radiofrequency ablation (CMBRFA) is an effective treatment for this health issue. Trident Multi-tined Cannula is also a way to help people with cervical pain. Research is needed to learn the characteristics and effectiveness of Trident Multi-tined Cannula compared to CMBRFA. The information we gain may aid future patients. (IRB#: IRB_00143800)
Foot and Ankle Shape Differences in Children and Teens with Various Types of Charcot Marie Tooth Disease
Charcot Marie Tooth (CMT) disease causes changes in the foot and ankle that can lead to pain and loss of function. This study intends to identify potential differences in bone and muscle structure between children and teens ages 8 to 18 years old with and without CMT. The study also wants to know the difference between genetic subtypes of CMT. This study will learn more about the disease to help develop new treatments. Participants with and without CMT will have two types of medical imaging done to make models of the bones and muscles in the foot and ankle. Participants with CMT will also receive genetic testing to identify their specific subtype of CMT. Participation lasts about 8 hours for those with CMT or 6 hours for those without CMT. Medical tests will be done throughout the study. (IRB#: IRB_00172882)
Intracept Procedure for People with Low Back Pain
Vertebrogenic low back painis caused by damage to parts of the spine called vertebral endplates. The damage can develop over time with the wear and tear on the back that comes from everyday activities. Vertebrogenic pain is usually felt in the middle of the low back and is often made worse by physical activity, prolonged sitting, bending forward, and lifting objects. The Intracept procedure is a treatment for low back pain. The procedure targets the basivertebral nerve, which is the nerve that sends pain signals from damaged endplates. The treatment has been shown to relieve pain long-term. This study will collect information from participants who are already scheduled to be treated for low back pain using the Intracept system. Participants in the study will complete surveys before and after the procedure. Participants may be asked to have a magnetic resonance imaging (MRI) of the lower back. An MRI is a tool used to take images of inside the body. Being in the study requires attending up to 12 study visits at the study clinic or at home. The study will track the health of participants for about 5 years after the Intracept treatment. (IRB#: IRB_00186240)
Laser Evoked Potentials (LEP) in Patients with Low Back Pain and Healthy Volunteers
People with low back pain may need testing for diagnoses and treatment evaluations. Research is needed to assess if more quantitative measures such as laser evoked potential (LEP) and quantitative sensory testing can be used to tease out differences in patients with low back pain problems and better determine the treatment outcomes. The information we gain may aid future patients. (IRB#: IRB_00158608)
Low-Cost Platelet-Rich Plasma for Managing Orthopedic Complications of Bleeding Disorders
Orthopedic complications can be injuries or diseases that affect the bones, muscles, and joints. Hemarthropathy is due to bleeding disorders, most commonly hemophilia, and can result in severe issues related to chronic amounts of blood in the bodys joints. This causes swelling, pain, and loss of joint function. A serious barrier to treating many patients with bleeding disorders creates higher health risks and costs. Platelet-rich plasma (PRP) injection is a method that can reduce the cost of care while still offering a similar standard of care for patients. This study intends to show that low-cost PRP can be done safely in patients with bleeding disorders, without the need for expensive equipment, while monitoring patient treatment results. People in the study will receive injections for joint conditions. Being in the study requires attending 1 to 2 in-person visits at the study clinic. People will also complete surveys using email, text messages, in person, and/or on the phone. Participation lasts about 6 months. (IRB#: IRB_00177846)
Metformin and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults may harm muscle health. Research is needed to learn of ways to improve the muscle response to physical activity and recovery. We will determine if metformin, a diabetes drug, improves muscle recovery during physical inactivity. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00175808)
MODEL Study: SB-01, A Study Drug for People with Degenerative Disc Disease in the Lower Back of the Spine
Degenerative disc disease can occur in the lower back of a persons spine. This disease can cause severe back pain and cause disability. SB-01 is a study drug to help people with this disease. Research is needed to study the safety and effectiveness of this drug. The information we gain may aid future patients. (IRB#: IRB_00154298)
Percutaneous Peripheral Nerve Stimulation (PNS): A Therapy for People with Chronic Low Back Pain (LBP)
Chronic low back pain (LBP) is a major health concern for many people. Many current therapies to help LBP do not work well. Percutaneous peripheral nerve stimulation (PNS) has been shown to relieve LBP and improve quality of life. Research is needed to learn the safety and effectiveness of percutaneous PNS. The information we learn may aid future patients. (IRB#: IRB_00132843)
Physical Inactivity and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults and those who are overweight may harm muscle health. Research is needed to learn how different markers such as hormones and proteins in the blood and muscle respond to physical activity and recovery. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00130232)
Psychedelic Use and People with Neurological or Musculoskeletal Injuries
This study wants to understand better the experiences of people who have had neurological or musculoskeletal injuries, including spinal cord injury, brain injury, stroke, and limb loss, in relation to using psychedelics (a type of drug). People in the study will complete a survey that lasts about 10 minutes. The survey will help the study learn about peoples experiences using psychedelics. The study wants to see how these experiences have influenced the ability to adapt to an injury/disability, mental health, and any medical symptoms or side effects. (IRB#: IRB_00175868)
Shoulder RFA for the Treatment of Non-Surgical Shoulder Pain
Shoulder pain can cause chronic health issues and costs. Currently, there are not many options to help people with this condition. Research is needed to learn the safety and effectiveness of shoulder radiofrequency ablation (SRFA) in patients with specific shoulder pain. The information we gain may aid future patients. (IRB#: IRB_00159158)
Studying Exercise Intolerance Symptoms for People with Long COVID
Exercise intolerance is the need to stop physical activity because of symptoms like shortness of breath and fatigue. Post-exertional malaise (PEM) is the worsening of symptoms after minimal physical, mental, or emotional activity. PEM symptoms include difficulty with physical activity (exercise intolerance), difficulty thinking, trouble sleeping, sore throat, headaches, muscle aches, dizziness, or severe tiredness. This study will find out if certain study interventions can help treat exercise intolerance and post-exertional malaise that started or got worse after a COVID-19 infection and has lasted for at least 3 months. Based on symptoms and then by chance, people in the study will be in one of two groups. One group will receive exercise training with education to help with exercise intolerance and improve quality of life and ability to exercise. The other group will receive a training intervention designed to help people with PEM to know, control, and minimize PEM symptoms. People in the study will wear an activity tracker on the wrist connected to the smartphone. Being in the study lasts about 6 months. (IRB#: IRB_00179021)
Testing Balance after Concussion
A mild traumatic brain injury (mTBI) also known as a concussion can occur when a person's head is hit by something or violently shaken. This study will learn how concussion affects balance and walking. Being in the study requires a persons balance and walking to be tested. People in the study will attend one visit to the study clinic. The visit will last about 3 hours. People will be given a small device to wear for 7 days to record normal daily activities. People will receive payment for participation. (IRB#: IRB_00180660)
The Effect of Planning to Balance During Walking, Stepping, or Jumping Interruptions
Research is needed to find how people balance during expected or unexpected walking, stepping, or jumping. interruptions. The information we learn will help us better understand how to support people with balancing challenges. (IRB#: IRB_00145032)
The SPRINT® System a Nerve Stimulator for People with Head Pain
The SPRINT® system can block nerves that send pain signals to the brain. Research is needed to learn how safe the SPRINT® system stimulator is and how well it helps people with head pain. The information we gain may aid future patients. (IRB#: IRB_00159617)
Thigh Muscle Changes Following Knee Injury and Surgery
The purpose of this study is to learn more about muscle function after joint injury of the knee. Including the characteristics of muscle changes and whether it is related to how the muscle functions (strength). The information may improve health care and quality of life for people following knee injuries. People will have medical procedures done to see an image of the leg and strength of the leg and have a biopsy (taking a small sample of tissue out of the muscle). Healthy people will attend in person at the study clinic for about 3 hours. People planning to have surgery for the medical condition will attend 3 study visits for a total of about 4-6 hours over 4 months. People will be paid for participation. (IRB#: IRB_00165256)