Search Criteria: Bone and Muscle Studies;
Lumbar Radiofrequency Ablation for People with Low Back Pain
Lumbar radiofrequency ablation (LRFA) is a treatment used to prevent a targeted nerve in the body from sending pain signals to the brain. This study will compare treatments for low back pain. Participants with chronic low back pain will be randomly assigned to a lumbar radiofrequency ablation (LRFA) or another treatment that may improve pain. The study wants to learn how well LRFA works to improve low back pain. Study participation will take about 3 to 4 hours over 12 months. (IRB#: IRB_00181348)
A Medtronic Product Follow-up Registry
This study will collect information into a follow-up registry from people who have used or intend to use a Medtronic Product. The information collected will be to continue Medtronic product safety and effectiveness and understand the range of product usage in clinical environments such as hospitals. This will help guide development and improvement of medical devices and therapies for patients that inform clinical research. People in the study will provide health information. This includes medical records, interviews, phone calls, mail, emails from the participant, family members, and/or doctors or other health providers. Participants will attend all regularly scheduled doctor visits, tell doctors about medical history, and report any health events such as injuries or hospitalizations. There is no registry end date. (IRB#: IRB_00184960)
Cervical Medial Branch Radiofrequency Ablation (CMBRFA) compared to Trident Multi-tined Cannula for People with Cervical Facet Pain
Cervical facet pain is an arthritis-like joint pain that can be chronic and occur in the back and neck of the spine. Cervical medial branch radiofrequency ablation (CMBRFA) is an effective treatment for this health issue. Trident Multi-tined Cannula is also a way to help people with cervical pain. Research is needed to learn the characteristics and effectiveness of Trident Multi-tined Cannula compared to CMBRFA. The information we gain may aid future patients. (IRB#: IRB_00143800)
Comparing Ultra-Low Frequency Spinal Cord Stimulation to Conventional Medical Management for People with Chronic Low Back Pain
This study wants to see how well Ultra-Low Frequency therapy compares to Conventional Medical Management in participants with chronic low back pain. Participants will be randomly chosen to be treated with Ultra-Low Frequency therapy along with Conventional Medical Management or Conventional Medical Management alone. Being in the study requires attending up to 17 in-person visits at the study clinic over about 27 to 33 months. Medical tests will be done throughout the study to track the health of participants. (IRB#: IRB_00179202)
Foot and Ankle Shape Differences in Children and Teens with Various Types of Charcot Marie Tooth Disease
Charcot Marie Tooth (CMT) disease causes changes in the foot and ankle that can lead to pain and loss of function. This study intends to identify potential differences in bone and muscle structure between children and teens ages 8 to 18 years old with and without CMT. The study also wants to know the difference between genetic subtypes of CMT. This study will learn more about the disease to help develop new treatments. Participants with and without CMT will have two types of medical imaging done to make models of the bones and muscles in the foot and ankle. Participants with CMT will also receive genetic testing to identify their specific subtype of CMT. Participation lasts about 8 hours for those with CMT or 6 hours for those without CMT. Medical tests will be done throughout the study. (IRB#: IRB_00172882)
Improving Human Movement with Wearable Devices
This study will learn how to design wearable devices and mobile sensors to measure human movement in the real world. This will help improve movement for people with conditions like stroke, osteoarthritis, and neuromuscular diseases such as Muscular Dystrophy (MS). People in the study will perform activities of daily living such as walking, walking on a treadmill, reaching, and squatting. The study will collect information about performing the activities with specific methods such as video recording or wearable devices. Being in the study requires completing up to 5 visits at the study clinic with each visit lasting 1 to 4 hours. (IRB#: IRB_00186623)
Intracept Procedure for People with Low Back Pain
Vertebrogenic low back painis caused by damage to parts of the spine called vertebral endplates. The damage can develop over time with the wear and tear on the back that comes from everyday activities. Vertebrogenic pain is usually felt in the middle of the low back and is often made worse by physical activity, prolonged sitting, bending forward, and lifting objects. The Intracept procedure is a treatment for low back pain. The procedure targets the basivertebral nerve, which is the nerve that sends pain signals from damaged endplates. The treatment has been shown to relieve pain long-term. This study will collect information from participants who are already scheduled to be treated for low back pain using the Intracept system. Participants in the study will complete surveys before and after the procedure. Participants may be asked to have a magnetic resonance imaging (MRI) of the lower back. An MRI is a tool used to take images of inside the body. Being in the study requires attending up to 12 study visits at the study clinic or at home. The study will track the health of participants for about 5 years after the Intracept treatment. (IRB#: IRB_00186240)
Laser Evoked Potentials (LEP) in Patients with Low Back Pain and Healthy Volunteers
People with low back pain may need testing for diagnoses and treatment evaluations. Research is needed to assess if more quantitative measures such as laser evoked potential (LEP) and quantitative sensory testing can be used to tease out differences in patients with low back pain problems and better determine the treatment outcomes. The information we gain may aid future patients. (IRB#: IRB_00158608)
Metformin and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults may harm muscle health. Research is needed to learn of ways to improve the muscle response to physical activity and recovery. We will determine if metformin, a diabetes drug, improves muscle recovery during physical inactivity. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00175808)
Physical Inactivity and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults and those who are overweight may harm muscle health. Research is needed to learn how different markers such as hormones and proteins in the blood and muscle respond to physical activity and recovery. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00130232)
Platelet Rich Plasma (PRP) for the Treatment of People with Musculoskeletal Conditions
This study will see the impact of pain and physical function after a Platelet Rich Plasma (PRP) treatment in people with musculoskeletal issues. PRP is a treatment derived from a persons own blood and has gained attention for its potential to improve pain and function in musculoskeletal conditions. People in the study will attend one in-person visit at the study clinic for the PRP injection and then have five follow-up events via email and/or telephone over about 12 months to complete surveys. (IRB#: IRB_00191115)
Psychedelic Use and People with Neurological or Musculoskeletal Injuries
This study wants to understand better the experiences of people who have had neurological or musculoskeletal injuries, including spinal cord injury, brain injury, stroke, and limb loss, in relation to using psychedelics (a type of drug). People in the study will complete a survey that lasts about 10 minutes. The survey will help the study learn about peoples experiences using psychedelics. The study wants to see how these experiences have influenced the ability to adapt to an injury/disability, mental health, and any medical symptoms or side effects. (IRB#: IRB_00175868)
Shoulder RFA for the Treatment of Non-Surgical Shoulder Pain
Shoulder pain can cause chronic health issues and costs. Currently, there are not many options to help people with this condition. Research is needed to learn the safety and effectiveness of shoulder radiofrequency ablation (SRFA) in patients with specific shoulder pain. The information we gain may aid future patients. (IRB#: IRB_00159158)
Studying Exercise Intolerance Symptoms for People with Long COVID
Exercise intolerance is the need to stop physical activity because of symptoms like shortness of breath and fatigue. Post-exertional malaise (PEM) is the worsening of symptoms after minimal physical, mental, or emotional activity. PEM symptoms include difficulty with physical activity (exercise intolerance), difficulty thinking, trouble sleeping, sore throat, headaches, muscle aches, dizziness, or severe tiredness. This study will find out if certain study interventions can help treat exercise intolerance and post-exertional malaise that started or got worse after a COVID-19 infection and has lasted for at least 3 months. Based on symptoms and then by chance, people in the study will be in one of two groups. One group will receive exercise training with education to help with exercise intolerance and improve quality of life and ability to exercise. The other group will receive a training intervention designed to help people with PEM to know, control, and minimize PEM symptoms. People in the study will wear an activity tracker on the wrist connected to the smartphone. Being in the study lasts about 6 months. (IRB#: IRB_00179021)
Testing a Non-Invasive, Magnetic Resonance Guided Focused Ultrasound System to Treat the Spine
This study will test an investigational device (not yet approved by the Federal Drug Administration) called Magnetic Resonance Imaging-guided Focused Ultrasound (MRgFUS) to develop a new non-invasive treatment for spinal pain. The device allows targeting very small volumes of tissue inside the body without affecting any other part of the body. This new device may one day offer patients an alternative therapy to surgical or more invasive treatments and reduce the amount of pain medications needed. People in the study will have a magnetic resonance imaging (MRI) exam similar to a routine MRI scan to take an image of the spine. Being in the study requires attending one in-person visit at the study clinic for up to 1 hour. People will receive payment for participation. (IRB#: IRB_00137036)
Testing Balance after Concussion
A mild traumatic brain injury (mTBI) also known as a concussion can occur when a person's head is hit by something or violently shaken. This study will learn how concussion affects balance and walking. Being in the study requires a persons balance and walking to be tested. People in the study will attend one visit to the study clinic. The visit will last about 3 hours. People will be given a small device to wear for 7 days to record normal daily activities. People will receive payment for participation. (IRB#: IRB_00180660)
The Effect of Planning to Balance During Walking, Stepping, or Jumping Interruptions
Research is needed to find how people balance during expected or unexpected walking, stepping, or jumping. interruptions. The information we learn will help us better understand how to support people with balancing challenges. (IRB#: IRB_00145032)
The SPRINT® System a Nerve Stimulator for People with Head Pain
The SPRINT® system can block nerves that send pain signals to the brain. Research is needed to learn how safe the SPRINT® system stimulator is and how well it helps people with head pain. The information we gain may aid future patients. (IRB#: IRB_00159617)
Thigh Muscle Changes Following Knee Injury and Surgery
The purpose of this study is to learn more about muscle function after joint injury of the knee. Including the characteristics of muscle changes and whether it is related to how the muscle functions (strength). The information may improve health care and quality of life for people following knee injuries. People will have medical procedures done to see an image of the leg and strength of the leg and have a biopsy (taking a small sample of tissue out of the muscle). Healthy people will attend in person at the study clinic for about 3 hours. People planning to have surgery for the medical condition will attend 3 study visits for a total of about 4-6 hours over 4 months. People will be paid for participation. (IRB#: IRB_00165256)