Search Criteria: Bone and Muscle Studies;
Lumbar Radiofrequency Ablation for People with Low Back Pain
Lumbar radiofrequency ablation (LRFA) is a treatment used to prevent a targeted nerve in the body from sending pain signals to the brain. This study will compare treatments for low back pain. Participants with chronic low back pain will be randomly assigned to a lumbar radiofrequency ablation (LRFA) or another treatment that may improve pain. The study wants to learn how well LRFA works to improve low back pain. Study participation will take about 3 to 4 hours over 12 months. (IRB#: IRB_00181348)
A Medtronic Product Follow-up Registry
This study will collect information into a follow-up registry from people who have used or intend to use a Medtronic Product. The information collected will be to continue Medtronic product safety and effectiveness and understand the range of product usage in clinical environments such as hospitals. This will help guide development and improvement of medical devices and therapies for patients that inform clinical research. People in the study will provide health information. This includes medical records, interviews, phone calls, mail, emails from the participant, family members, and/or doctors or other health providers. Participants will attend all regularly scheduled doctor visits, tell doctors about medical history, and report any health events such as injuries or hospitalizations. There is no registry end date. (IRB#: IRB_00184960)
A Registry Study Following the Outcomes of Patients Receiving Standard of Care Treatment for Pain due to Osteoarthritis of the Knee
In this study, we are looking for people who are planning to start a new standard medical treatment or procedure for knee pain caused by osteoarthritis. The main goal of this study is to compare how well these common treatments work to reduce your knee pain. We will collect information about you, including your medical history and any past treatments or medications you have used for knee pain caused by osteoarthritis. We will also gather information about your new treatment and how well it works by asking you to fill out questionnaires. Some of these questionnaires will be completed using a diary app on your own phone or tablet. If you are scheduled to have knee replacement surgery, we will collect information about how well the surgery works. We will also record information about the costs of different treatments. Your participation in the study will last about 20 months. (IRB#: IRB_00199394)
A Study to Evaluate the Safety and Effectiveness of Injectable Disc Cell Therapy for Patients Who Have Mild to Moderate Lumbar Disc Degeneration
The purpose of this research is to find out if the experimental drug, Injectable Disc Cell Therapy (IDCT), is safe and effective in treating symptomatic lumbar degenerative disc disease. (IRB#: IRB_00194600)
Cervical Medial Branch Radiofrequency Ablation (CMBRFA) compared to Trident Multi-tined Cannula for People with Cervical Facet Pain
Cervical facet pain is an arthritis-like joint pain that can be chronic and occur in the back and neck of the spine. Cervical medial branch radiofrequency ablation (CMBRFA) is an effective treatment for this health issue. Trident Multi-tined Cannula is also a way to help people with cervical pain. Research is needed to learn the characteristics and effectiveness of Trident Multi-tined Cannula compared to CMBRFA. The information we gain may aid future patients. (IRB#: IRB_00143800)
Dynamic Adult Flatfoot Morphology and Kinematics
This study is trying to learn more about how the feet and ankles work in adults who have flatfeet and those who do not. We want to understand how flatfeet caused by neurological conditions (like cerebral palsy) and flatfeet not caused by neurological issues affect a persons quality of life. We are looking for adults with and without cerebral palsy. You may also join if you have had foot surgery, have flatfeet, or do not have any foot problems. This study involves one visit that will take about 4 hours at the University of Utah Research Park. To join, you must be able to walk at least 10 meters (about 33 feet) with little or no help. Participants will receive compensation for taking part in the study. (IRB#: IRB_00142936)
Foot and Ankle Shape Differences in Children and Teens with Various Types of Charcot Marie Tooth Disease
Charcot Marie Tooth (CMT) disease causes changes in the foot and ankle that can lead to pain and loss of function. This study intends to identify potential differences in bone and muscle structure between children and teens ages 8 to 18 years old with and without CMT. The study also wants to know the difference between genetic subtypes of CMT. This study will learn more about the disease to help develop new treatments. Participants with and without CMT will have two types of medical imaging done to make models of the bones and muscles in the foot and ankle. Participants with CMT will also receive genetic testing to identify their specific subtype of CMT. Participation lasts about 8 hours for those with CMT or 6 hours for those without CMT. Medical tests will be done throughout the study. (IRB#: IRB_00172882)
Growth and Development of Flatfoot in Kids and Teens with Advanced Imaging Methods
Flatfoot, or planus deformity, affects the function and movement of the foot and ankle. This can cause pain or discomfort while doing activities. Flatfoot is seen in children and teenagers with neurologic conditions such as Cerebral Palsy. Flatfoot is also seen on its own without any neurologic involvement or symptoms. Neurologic conditions concern the nervous system, which includes the brain, spinal cord, and all nerves in the body. This study wants to learn the changes in flat feet and the bone shape of feet as children and teenagers grow. People in the study will have a special CT (computer tomography) scan done to take pictures of the bones in a standing position. Special cameras and reflective stickers will also be used to learn more about how children and teenagers walk. The scans and tests will be done once a year for 3 years in a row. (IRB#: IRB_00190439)
Improving Human Movement with Wearable Devices
This study will learn how to design wearable devices and mobile sensors to measure human movement in the real world. This will help improve movement for people with conditions like stroke, osteoarthritis, and neuromuscular diseases such as Muscular Dystrophy (MS). People in the study will perform activities of daily living such as walking, walking on a treadmill, reaching, and squatting. The study will collect information about performing the activities with specific methods such as video recording or wearable devices. Being in the study requires completing up to 5 visits at the study clinic with each visit lasting 1 to 4 hours. (IRB#: IRB_00186623)
Intracept Procedure for People with Low Back Pain
Vertebrogenic low back painis caused by damage to parts of the spine called vertebral endplates. The damage can develop over time with the wear and tear on the back that comes from everyday activities. Vertebrogenic pain is usually felt in the middle of the low back and is often made worse by physical activity, prolonged sitting, bending forward, and lifting objects. The Intracept procedure is a treatment for low back pain. The procedure targets the basivertebral nerve, which is the nerve that sends pain signals from damaged endplates. The treatment has been shown to relieve pain long-term. This study will collect information from participants who are already scheduled to be treated for low back pain using the Intracept system. Participants in the study will complete surveys before and after the procedure. Participants may be asked to have a magnetic resonance imaging (MRI) of the lower back. An MRI is a tool used to take images of inside the body. Being in the study requires attending up to 12 study visits at the study clinic or at home. The study will track the health of participants for about 5 years after the Intracept treatment. (IRB#: IRB_00186240)
Laser Evoked Potentials (LEP) in Patients with Low Back Pain and Healthy Volunteers
People with low back pain may need testing for diagnoses and treatment evaluations. Research is needed to assess if more quantitative measures such as laser evoked potential (LEP) and quantitative sensory testing can be used to tease out differences in patients with low back pain problems and better determine the treatment outcomes. The information we gain may aid future patients. (IRB#: IRB_00158608)
Long-term study of foot and ankle anatomy in children and teens with Charcot-Marie-Tooth Disease
CharcotMarieTooth (CMT) disease can affect how the feet and ankles grow and move. This study looks at how the bones and muscles in the feet and ankles change over time in children and teens with CMT. What we learn may help improve future treatments. The study includes three visits over two years. Children and teens with and without CMT will have medical imaging to take pictures of their feet and ankles. Those with CMT will also have genetic testing and simple tests of muscle strength, hand use, and walking. The movement tests will be repeated after one year and after two years. (IRB#: IRB_00195630)
Metformin and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults may harm muscle health. Research is needed to learn of ways to improve the muscle response to physical activity and recovery. We will determine if metformin, a diabetes drug, improves muscle recovery during physical inactivity. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00175808)
Physical Inactivity and Muscle Health Recovery
Times of physical inactivity such as illness, recovery from surgery, or injury in older adults and those who are overweight may harm muscle health. Research is needed to learn how different markers such as hormones and proteins in the blood and muscle respond to physical activity and recovery. The information we gain may allow us to better design ways to help muscle health when older adults or those who are overweight become physically inactive and have rehabilitation. (IRB#: IRB_00130232)
Platelet Rich Plasma (PRP) for the Treatment of People with Musculoskeletal Conditions
This study will see the impact of pain and physical function after a Platelet Rich Plasma (PRP) treatment in people with musculoskeletal issues. PRP is a treatment derived from a persons own blood and has gained attention for its potential to improve pain and function in musculoskeletal conditions. People in the study will attend one in-person visit at the study clinic for the PRP injection and then have five follow-up events via email and/or telephone over about 12 months to complete surveys. (IRB#: IRB_00191115)
Psychedelic Use and People with Neurological or Musculoskeletal Injuries
This study wants to understand better the experiences of people who have had neurological or musculoskeletal injuries, including spinal cord injury, brain injury, stroke, and limb loss, in relation to using psychedelics (a type of drug). People in the study will complete a survey that lasts about 10 minutes. The survey will help the study learn about peoples experiences using psychedelics. The study wants to see how these experiences have influenced the ability to adapt to an injury/disability, mental health, and any medical symptoms or side effects. (IRB#: IRB_00175868)
Research study designed to understand the body's response to viewing activities that require back movement using a virtual reality 3D pictures in persons with chronic low back pain
People with long-term low back pain often experience anxiety when they move their backs during daily activities. These reactions can happen very quickly and are difficult to measure using surveys alone. In this study, participants with chronic low back pain will view images of back movement while we measure natural body responses such as heart rate, breathing, and skin sweating. Participants will complete two sessions: one using a virtual reality headset and one using a computer screen. We will compare how the body responds in each setting. This study is not expected to provide direct benefit to participants, but the results may help improve future evaluation and treatment of movement-related anxiety in people with chronic low back pain. (IRB#: IRB_00199448)
SHAM-PAIN Trial: Knee Artery Embolization to Reduce Pain in those who have Osteoarthritis
The main goal of this study is to see if we can sign people up and place them into either the real Genicular Artery Embolization (GAE) procedure or the sham (pretend) procedure. We also want to see how their knee pain changes over time. We will compare pain levels between the people who get the real GAE procedure and the people who get the sham one. We will check their pain every 3 months for up to 12 months. In this study, we use a procedure called embolization, which uses Xrays. There is also a sham procedure, which is a pretend version. During the sham procedure, the doctor does all the same steps as the real procedure, but does not block any blood flow. Only Dr. Ahmed and the study statisticians will know whether you get the real GAE procedure or the sham one. You will not know. A computer will choose which one you get at random, like flipping a coin. This helps the researchers see if GAE works better than a placebo (a fake treatment). If you are chosen for the sham procedure, you can get the real GAE procedure after 3 months at no additional cost. This section gives you the most important information to help you decide if you want to join the study. More details are included later. You can ask the research team any questions you have. If you have questions later, you can contact the study doctor using the information listed above. (IRB#: IRB_00196043)
Studying Exercise Intolerance Symptoms for People with Long COVID
Exercise intolerance is the need to stop physical activity because of symptoms like shortness of breath and fatigue. Post-exertional malaise (PEM) is the worsening of symptoms after minimal physical, mental, or emotional activity. PEM symptoms include difficulty with physical activity (exercise intolerance), difficulty thinking, trouble sleeping, sore throat, headaches, muscle aches, dizziness, or severe tiredness. This study will find out if certain study interventions can help treat exercise intolerance and post-exertional malaise that started or got worse after a COVID-19 infection and has lasted for at least 3 months. Based on symptoms and then by chance, people in the study will be in one of two groups. One group will receive exercise training with education to help with exercise intolerance and improve quality of life and ability to exercise. The other group will receive a training intervention designed to help people with PEM to know, control, and minimize PEM symptoms. People in the study will wear an activity tracker on the wrist connected to the smartphone. Being in the study lasts about 6 months. (IRB#: IRB_00179021)
Testing a Non-Invasive, Magnetic Resonance Guided Focused Ultrasound System to Treat the Spine
This study will test an investigational device (not yet approved by the Federal Drug Administration) called Magnetic Resonance Imaging-guided Focused Ultrasound (MRgFUS) to develop a new non-invasive treatment for spinal pain. The device allows targeting very small volumes of tissue inside the body without affecting any other part of the body. This new device may one day offer patients an alternative therapy to surgical or more invasive treatments and reduce the amount of pain medications needed. People in the study will have a magnetic resonance imaging (MRI) exam similar to a routine MRI scan to take an image of the spine. Being in the study requires attending one in-person visit at the study clinic for up to 1 hour. People will receive payment for participation. (IRB#: IRB_00137036)
Testing Balance after Concussion
A mild traumatic brain injury (mTBI) also known as a concussion can occur when a person's head is hit by something or violently shaken. This study will learn how concussion affects balance and walking. Being in the study requires a persons balance and walking to be tested. People in the study will attend one visit to the study clinic. The visit will last about 3 hours. People will be given a small device to wear for 7 days to record normal daily activities. People will receive payment for participation. (IRB#: IRB_00180660)
Testing the Drug SL1002 for People with Knee Osteoarthritis
Knee Osteoarthritis causes pain and stiffness in the knee, which can reduce mobility. This study will test a drug called SL1002 to treat people with this condition. The study wants to see if the drug will help people with the condition and is safe. Participants in the study will be randomly assigned to receive SL1002 or a placebo via injection into the knee. A placebo looks like the study drug but does not have the medication. People will also complete surveys. Being in the study requires attending 7 in-person visits to the study clinic over 6 months. Each visit lasts about 2 hours. Medical tests will be done during the study to track the health of participants. (IRB#: IRB_00196475)
Thigh Muscle Changes Following Knee Injury and Surgery
The purpose of this study is to learn more about muscle function after joint injury of the knee. Including the characteristics of muscle changes and whether it is related to how the muscle functions (strength). The information may improve health care and quality of life for people following knee injuries. People will have medical procedures done to see an image of the leg and strength of the leg and have a biopsy (taking a small sample of tissue out of the muscle). Healthy people will attend in person at the study clinic for about 3 hours. People planning to have surgery for the medical condition will attend 3 study visits for a total of about 4-6 hours over 4 months. People will be paid for participation. (IRB#: IRB_00165256)