Search Criteria: Heart Studies;
A Laryngeal Nerve Factor in Vocal Fold Paralysis
A Laryngeal nerve is what helps people swallow, breathe, and have vocal cord movement in the neck. This study wants to learn how the blood vessels of people with a neurological voice disorder compare to people without a voice disorder. A neurological voice disorder is a condition that makes it difficult for a person to speak. People in the study will participate in a Magnetic Resonance Imaging (MRI) scan. The MRI forms an image of the blood vessels of the laryngeal nerve. People will share medical history with the study team. Participation requires about 1 visit to the study clinic. (IRB#: IRB_00097852)
A Study to Test a Tool to Help People for Anticoagulant Drug-to-Drug Interactions
This study is to better understand the safety of oral anticoagulants (medicine for people taken by mouth to prevent blood clots) which may increase the risk of bleeding events if taken with other medications. Researchers at the University of Utah have developed an app called DDInteract to use on a technology device like a cell phone that allows doctors and patients to make decisions about drug reactions with oral anticoagulants and other medications. We want to see if using the app helps patients and their doctors learn and reduce the risks of taking anticoagulants with other medications. People in this study will participate in a virtual focus group (a discussion together with several people using technology such as a cell phone or computer). The information we gain will help us learn more about the effects of taking oral anticoagulants with other drugs. (IRB#: IRB_00167936)
Building Transition Readiness Skills for Adolescents and Young Adults with Congenital Heart Disease
Congenital heart disease (CHD) is one of the most common birth defects with most major effects diagnosed in infancy. Because there is no cure for CHD it is a lifelong chronic illness. Research is needed to understand the needs of people with CHD as they transition from child to adulthood. This information will improve the care and quality of life for people with CHD. (IRB#: IRB_00156291)
Circadian Timing and Chronic Disease
Circadian timing is when a person's daily behaviors occur such as eating and sleeping. Circadian timing may affect a persons health and well-being. Research is needed to learn if improving circadian timing impacts body metabolism (how a person processes and uses food). Which may lead to chronic diseases such as diabetes and heart disease. The research we gain may aid future patients. (IRB#: IRB_00159535)
Computer Model of Abnormal Heart Rhythm
Arrhythmias is the improper beating of the heart. This study wants to learn more about peoples arrhythmias from the heart's upper chamber. This happens when people have had an ablation for a heart condition called atrial fibrillation (rapid heart rate). An ablation is done to improve the heart condition. People in the study will be planning a redo ablation and have procedures that generally take place and are not done specifically for the study, such as an MRI (a tool used to see inside the body). This will help show areas of scar tissue in the atrium. Additional ablation may also take place. Being in the study requires attending regularly scheduled in-person visits to the clinic related to ablation. Medical information will be collected to see the heart's rhythm for up to 5 years. This study will use scar information to make a computer model of the arrhythmia and use that to guide treatment. (IRB#: IRB_00128325)
Creating an Educational Tool for People Using Anticoagulants
Anticoagulants are drugs used to thin the blood and stop the blood from clotting. The drug is already approved for use. The study wants to develop an online tool to teach people about the drug. The study wants to learn what people need to create the tool. People in the study will participate in person at a study clinic for about 30-60 minutes of interviews. People will also spend time using the tool while being observed and video recorded. Participants will be paid for being in the study. (IRB#: IRB_00175039)
Cuffless Blood Pressure Study in Patients with Cardiovascular Conditions
This study aims to test bioimpedance technology to measure blood pressure in patients. Normally people measure their blood pressure with an inflatable cuff on their arm. Bioimpedance technology involves placing sensors in the skin for non invasive recordings. People in this study will wear this new device at the Heart Failure Clinic at the University of Utah Medical Center. These will help us get more measurements to see if the technology works. The study session will last about 30 minutes. (IRB#: IRB_00170063)
How does kidney blood flow affect heart failure?
We want to learn how blood flow in the kidneys might affect heart failure. We will test some people with normal heart function and some with stable heart failure. We will also test some people with diabetes. The tests are a blood test, a urine test, an MRI, an echocardiogram, and an ultrasound. We will also collect information about the medications you take and other medical problems you might have. (IRB#: IRB_00154546)
Improving Congenital Heart Disease Care for Adolescents and Young Adults
Congenital Heart disease (CHD) is one of the most common birth defects with most major effects diagnosed in infancy. Because there is no cure for CHD it is a lifelong chronic illness. Research is needed to understand the needs of people with CHD as they transition from child to adulthood. This information will improve the care and quality of life for people with CHD. (IRB#: IRB_00149991)
Improving MRI for People with Heart Disease
People with heart disease may need an imagining scan known as an MRI. Research is needed to improve MRI methods used for finding heart problems and better determining what is normal and what is a disease. These include myocardial fibrosis. The thickening of tissue in heart muscles. The information we gain may aid future patients. (IRB#: IRB_00154019)
Lifestyle Change Among Women at Risk for Heart Disease and Diabetes
More than half of women of childbearing age may be at risk for heart disease and diabetes. Research is needed to know if women who participate in lifestyle change programs have better health in future pregnancies. To do this we first want to learn women's knowledge about their risk of diabetes and heart disease. Second, we want to know what factors women think may help or prevent them from participating in a healthy lifestyle program. The information we gain may aid future women. (IRB#: IRB_00146361)
Magnetic Resonance Imaging (MRI) in Atherosclerotic Disease of the Carotid Artery
Atherosclerotic Disease is a buildup of fat, cholesterol, and other substances on artery walls. An MRI is a way to see places that may have buildup. Research is needed to improve the way an MRI automatically and accurately sees inside the artery walls. The information we gain may aid future patients. (IRB#: IRB_00143315)
Magnetic Resonance Imaging Development
Magnetic Resonance Imaging (MRI) is done to form pictures of inside the body. An MRI helps diagnose health issues. The purpose of this study is to improve MRI for better health diagnoses and exam experience. Being in the study requires attending one in-person study visit to have an MRI. The MRI procedure is conducted by lying down in a long cylinder. The study visit will last about 2 hours. (IRB#: IRB_00075295)
Near Infrared Spectroscopy to Detect Acute Kidney Injury During Cardiac Surgery
Acute kidney injury (AKI) is a complication of cardiac (heart) surgery. Near Infrared Spectroscopy (NIRS) is a technology that uses light to determine how well-oxygenated a persons body tissues are. This technology is routinely used in cardiac surgery to measure the oxygen level in a persons brain by placing a sensor sticker on the forehead. This study wants to test whether NIRS sensor stickers placed on the skin over the kidney can predict AKI better than when sensors are placed on the skin over the limbs such as the arms and legs. People in the study will receive normal care for cardiac surgery along with adding more sensor stickers placed on the body. Medical tests will be done during the study to track the health of participants. (IRB#: IRB_00179157)
New Magnetic Resonance Imaging (MRI) Software to Improve Diagnosis of People with Neurovascular Diseases.
Magnetic Resonance Imaging (MRI) is a way to form pictures inside of a persons body. A new MRI software has been designed to improve the quality and diagnosis of neurovascular diseases in the brain and surrounding areas. These diseases can cause problems in the muscles and nerves of a persons body. We want to learn if new MRI software creates better pictures to help people with neurovascular diseases. The information we gain may aid future patients. (IRB#: IRB_00162281)
Patient and Caregiver Perceptions of Family Wellbeing for Vascular Surgery
Vascular surgery may be done to treat a wide range of people with heart and blood flow issues. Many patients with this procedure can be at risk for other health problems and are over the age of 65. The purpose of this study is to learn more about the needs of the family well-being of vascular surgery patients. This will help doctors better understand decision-making for the family's well-being. People in this study will complete a one-time interview and one-time questionnaires. The interview will be conducted over the phone. Participants will be given a total of $100 for completion of the interview and questionnaires at each time point before and after surgery (IRB#: IRB_00166345)
Patients After a Stroke who Have Weakness in Either Arms or Legs
Paresis can occur after a person has a stroke causing weakness in either the arms or legs. People who have paresis are at risk of having spasticity. This is when the muscles stiffen or tighten without control and can cause pain. The study wants to see what patients 12 months after the first stroke have spasticity. Participants in the study will complete surveys by phone or online (such as using a computer) and attend in-person study visits. If allowed, the study visits may happen at home. The amount of time spent in the study varies and can last up to 18 months after the first stroke. Participants will be paid for being in the study. Medical information will be collected to track the health of participants. (IRB#: IRB_00169101)
Shared Decision-Making of People with Carotid Artery Stenosis and Their Caregivers
Carotid Arteries are the major blood vessels that carry blood to the brain. Carotid Artery Stenosis is a disease that narrows these arteries and increases the risk of a stroke. This study will learn from people with this disease and their caregivers to help develop guidelines for shared decision-making. Participants in the study will attend a 90-minute focus group to discuss experiences of living with Carotid Artery Stenosis as a patient and caregiver. (IRB#: IRB_00174805)
Sleep and Cardiometabolic Disease
Cardiometabolic disease may put a person at risk of diabetes and heart disease. The amount of time a person sleeps is one factor that can cause the risk of these health issues. Research is needed to learn specific ways to improve a person's nightly sleep that may lower disease risk. The research we gain may aid future patients. (IRB#: IRB_00164764)
Study Cuffless Blood Pressure
This study is developing a new device to measure blood pressure (how the force of blood goes throughout the body). Normally people measure their blood pressure with an inflatable cuff on their arm. The new device is like a wristwatch with a sensor for blood pressure. People in this study will wear the new device while they exercise in a lab at the University of Utah. Other vital signs will be measured such as body temperature and weight and use an ultrasound machine (a way to see the inside of the body). These will help get more measurements to see if the new device works. The study session will last about 90 minutes. (IRB#: IRB_00162369)
Studying the genetic factors in smoking-induced vascular disease
Our study will determine whether people who have genetic variants in nicotine receptors have a higher risk for smoking-induced vascular disease. Then we will study the mechanisms and identify potential therapy for smokers carrying genetic variants in nicotine receptors. Our study will educate people carrying genetic variants in nicotine receptors to stop smoking and will provide potential treatments against smoking-induced vascular disease for this population. (IRB#: IRB_00167355)
Sweet Dreams/Dulces Suenos
The purpose of this study is to learn about how women of color find time to sleep in their busy lives. As well as balancing sleep with other healthy behaviors and life demands. The study also wants to learn the impact of sleep on risk factors for cardiovascular (heart) disease and diabetes. The results from the study will help develop a new intervention to improve sleep for women. Being in the study requires attending a 90-minute in-person visit. During the visit participants will complete an online questionnaire, time use survey, and cardiometabolic assessment. After the in-person visit, participants will wear a Fitbit for 7 nights. During this time, participants will receive text messages each day to answer questions about the previous night and experiences that day. Participants will then complete a second time use survey. Participants will be paid for being in the study. (IRB#: IRB_00179415)
Testing a Gaming Approach to Improve Health for People with Atrial Fibrillation, Diastolic Heart Failure, or Obesity
This study will explore whether game-like elements can help people with health issues like atrial fibrillation (an irregular heartbeat), diastolic heart failure, or obesity. The study wants to see if reward-based, friendly competition and community support can encourage participants to reach health goals, like staying active, eating healthier, and tracking symptoms. Participants will sign up online and complete surveys about activity levels, diet, energy levels, and health symptoms. Through a website called Gardens, participants will log progress, earn points for staying active and completing health tasks, and monitor their health. Points will be redeemed for prizes, like gift cards or free wellness classes, and participants will see rankings on a leaderboard. (IRB#: IRB_00184498)
Testing a Video Game to Help Transition of Care for People with Congenital Heart Disease
Congenital heart disease (CHD) is one of the most common birth defects with most major effects diagnosed in infancy. There is no cure for CHD. It is a lifelong chronic illness. This study will test an educational video game to help young people with CHD. Being in the study requires testing the video game on a phone, computer, or tablet. Participants will provide feedback about the video game through a survey. People will be paid for participation. (IRB#: IRB_00179379)
Testing a Video Game to Transition Care for Teens with Congenital Heart Disease
Congenital heart disease is an abnormality in the heart. This study will test an educational game to help teens and young adults with the disease change from pediatric to adult care. People in the study will review the game and provide feedback. Being in the study requires completing a survey and attending one 30-minute session. People will be paid for participation. (IRB#: IRB_00167531)
Testing Effects of Wearable Sensors on Heart Implant Devices
This study tests heart implant response to wearable sensors using smartwatches and smart scales that measure health, such as weight and stress. People in the study must have a heart implant pacemaker or defibrillator more than 3 months before participation. People in the study will wear a smartwatch and stand on a smart scale. Participants will attend one in-person visit at the study clinic for about 1 hour. Medical tests will be done to track the health of participants. (IRB#: IRB_00177524)
Testing Nectero EAST in Adults with Small to Mid-Sized Abdominal Aortic Aneurysms
An abdominal aortic aneurysm is an enlarged artery or tube in your belly that carries blood from your heart to the rest of the body. When the abdominal aorta enlarges the wall weakens and stretches, eventually can get big and thin enough to burst open, which can bleed and cause death. Nectro EAST is a treatment designed to slow the growth and prevent the bursting of an abdominal aortic aneurysm and may decrease the need for surgery in the future. People in the study will be required to come in for in-person clinic visits and be followed for 5 years to monitor the growth of the aneurysm. People randomly chosen to be treated with Nectro EAST will undergo a one-time 1-hour surgery. The surgery is performed through the groin and uses a balloon to deliver medication directly to the aneurysm. The balloon is removed after and recovery is very minimal. Being in the study for both groups lasts 5 years and medical tests will be done to track the health of participants. (IRB#: IRB_00170182)
Testing New MRI Methods for People with Heart Disease
Magnetic resonance imaging (MRI) is a tool used to take an image of the inside of the body. There are previous and newly developed heart MRI methods to assess heart diseases. This study wants to better understand the use of these MRI methods to help people with health issues such as heart disease. People in the study will have an MRI which includes lying down inside of a cylinder and laying still for a certain amount of time. Being in the study requires attending at least one MRI appointment that will last up to 2.5 hours. (IRB#: IRB_00185568)
Testing the Drug Inclisiran for Adults with Atherosclerotic Cardiovascular Disease
This study will test an approved study drug, Inclisiran, to treat people with heart disease to see if it lowers bad cholesterol. The study wants to see if the drug will help people with the disease. People in the study will be randomly chosen to be treated with Inclisiran for the first 12 months (Part 1) of the study. If people in the study did not receive Inclisiran during Part 1 of the study, they will continue participation for another 12 months (Part 2) and receive Inclisiran in the second 12 months. Being in the study requires attending 4 or 7 in-person visits at the study clinic, which lasts 12 or 24 months, depending on the assigned group. Medical tests will be done to track the health of participants. (IRB#: IRB_00177770)
The Timing of Eating Food and Sleep Loss on a Person's Health
Sleep is an important factor for overall health. This study will see how different light exposure patterns and food intake impact a persons metabolism (how the body breaks down food) when sleeping is reduced. People in the study will attend about 6 to 8 in-person visits to that study clinic, including some overnight stays. People will complete surveys and medical tests. The study will last about 4 to 6 months. People will be paid to complete the study. (IRB#: IRB_00185590)