Study Details

Testing the Study Drug Vixarelimab for People with Moderate to Severe Ulcerative Colitis

(IRB#: IRB_00177806)

Ulcerative colitis is a disease that affects the intestine (helps digest food). This study will test a drug called Vixarelimab for people with moderate to severe ulcerative colitis. The study wants to see if the drug will help people and is safe. People in this study will be randomly chosen to be treated at various time points with Vixarelimab or a placebo. The placebo looks like the study drug but does not have the treatment. The study drug and placebo are given under the skin. People in the study will have a colonoscopy or flexible sigmoidoscopy that is video recorded at screening, week 12, and at the end of the study to assess disease activity. People will use an electronic diary on a handheld device to record study activity. Participation requires attending in-person visits at the study clinic and lasts about 25 weeks or 61 weeks if participants choose to be in an optional study. People are paid for participation. Medical tests will be done to track the health of participants.

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