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Study Details

Testing the Drug Lorundrostat in Adults with Uncontrolled Hypertension

(IRB#: IRB_00165346)

Uncontrolled Hypertension is when the blood flow in the body is too high against the arteries and is unable to be controlled. This study will test a drug called Lorundrostat or MLS-101 to treat adults with this condition. The study wants to see if the drug will help people with the health condition. People in this study will be randomly chosen to be treated into three different groups. One group will receive the same daily amount of Lorundrostat or MLS-10. Another group will receive the same daily amount and then increase the daily amount. While a different group receives a placebo. A placebo does not have the treatment. The drug and placebo are taken as a swallowed pill. Being in the study lasts up to 5 months with a total of 9 clinic visits. Participants will be paid $50.00 per visit. Medical tests are done to track the health of participants.


  • All genders
  • Over 18 years old
  • Volunteers with special conditions
  •   In Person
  • Paid

Who can participate?

 Gender: All genders

  Age: Over 18 years old

  Volunteers: Volunteers with special conditions

   Location: In Person

Inclusion Criteria

  • Ages 18 years and older
  • History of hypertension lasting 6 months prior to participation
  • Participants agree to use specific birth control methods
  • Attend in person at the study clinic

Exclusion Criteria

  • Pregnant or breastfeeding
  • Known allergy to Lorundrostat
  • Received treatment with Lorundrostat or another study drug or device 6 months prior to participation
  • Received medication for other chronic conditions such as heart disease or specific diabetes events that may affect participation
  • Hospitalized for major infection 2 months prior to participation and/or planning major surgery during or 4 weeks prior to participation

Will I be paid for my time?


For more information contact:

Inge Stijleman


IRB#: IRB_00165346

PI: Josephine Abraham


Approval Date: 2023-08-09 06:00:00

Specialties: Nephrology & Hypertension

Last Updated: 6/8/23